Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress (Q34346809)

1 August 2017

title

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress (English)

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1 August 2017

main subject

endoplasmic reticulum

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Joseph L Witztum

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1 August 2017

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Sotirios Tsimikas

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Douglas Golenbock

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1 August 2017

Marlys L Koschinsky

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Kathryn J. Moore

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Kathryn J Moore

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Richard Harkewicz

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object named as

Richard Harkewicz

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1 August 2017

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Tracie A Seimon

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1 August 2017

Marissa J Nadolski

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1 August 2017

Xianghai Liao

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1 August 2017

Jorge Magallon

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1 August 2017

Matthew Nguyen

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Nicole T Feric

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Ira Tabas

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1 August 2017

publication date

1 November 2010

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1 August 2017

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1 August 2017

volume

12

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1 August 2017

issue

5

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1 August 2017

page(s)

467-482

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Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

1 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.

6 July 2018

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6 July 2018

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A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

6 July 2018

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Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.

6 July 2018

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Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

6 July 2018

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6 July 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

6 July 2018

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

6 July 2018

1 reference

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The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Modulation of atherosclerosis in mice by Toll-like receptor 2

6 July 2018

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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

6 July 2018

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Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

6 July 2018

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Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

6 July 2018

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Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain

6 July 2018

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NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica

6 July 2018

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6 July 2018

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CD36 is a sensor of diacylglycerides

6 July 2018

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NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

6 July 2018

1 reference

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Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Structure-function relationships in apolipoprotein(a): insights into lipoprotein(a) assembly and pathogenicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Actin Polymerization in Macrophages in Response to Oxidized LDL and Apoptotic Cells: Role of 12/15-Lipoxygenase and Phosphoinositide 3-Kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Role of CD36 in membrane transport of long-chain fatty acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Role of reactive oxygen species (ROS) in apoptosis induction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991104

Changing concepts of atherogenesis

6 July 2018

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The visualization of oxidant stress in tissues and isolated cells

6 July 2018

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Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

6 July 2018

1 reference

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

6 July 2018

1 reference

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Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

6 July 2018

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6 July 2018

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CD36 is a receptor for oxidized low density lipoprotein

6 July 2018

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6 July 2018

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Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis

6 July 2018

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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

27 October 2018

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27 October 2018

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27 October 2018

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Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis

27 October 2018

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27 October 2018

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Phosphocholine as a pattern recognition ligand for CD36.

27 October 2018

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Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes

27 October 2018

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The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

27 October 2018

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27 October 2018

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Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a).

27 October 2018

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12 December 2020

Saturated fatty acids do not directly stimulate Toll-like receptor signaling

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10.1016/J.CMET.2010.09.010

Identifiers

DOI

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1 August 2017

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1 August 2017

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