The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. (Q34345666)

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21 February 2020

title

The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function (English)

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N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine

21 February 2020

main subject

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ChEBI release 2020-05-28

2

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21 February 2020

Hongtian Yang

4

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21 February 2020

Pablo E Castillo

8

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21 February 2020

author name string

Hailong Hou

1

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21 February 2020

Chih-Chieh Wang

3

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21 February 2020

Hua Gu

5

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21 February 2020

Benjamin A Siddoway

6

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21 February 2020

Benjamin J Hall

7

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21 February 2020

Houhui Xia

9

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21 February 2020

language of work or name

English

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publication date

1 October 2014

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21 February 2020

published in

Journal of Neuroscience

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21 February 2020

volume

34

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21 February 2020

issue

42

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21 February 2020

page(s)

14006-14012

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Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5

21 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration

6 July 2018

1 reference

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An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus

6 July 2018

1 reference

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The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB.

6 July 2018

1 reference

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Mechanisms of specificity in neuronal activity-regulated gene transcription

6 July 2018

1 reference

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Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus

6 July 2018

1 reference

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TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus.

6 July 2018

1 reference

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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

6 July 2018

1 reference

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Role of Rac1 GTPase in NADPH Oxidase Activation and Cognitive Impairment Following Cerebral Ischemia in the Rat

6 July 2018

1 reference

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Protein phosphatases 1 and 2A are both required for long‐term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Cognitive strategy-specific increases in phosphorylated cAMP response element-binding protein and c-Fos in the hippocampus and dorsal striatum.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

CREB phosphorylation and dephosphorylation: a Ca(2 )- and stimulus duration-dependent switch for hippocampal gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198541

A critical role for GluN2B-containing NMDA receptors in cortical development and function

6 July 2018

1 reference

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NR2B signaling regulates the development of synaptic AMPA receptor current.

27 October 2018

1 reference

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Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95.

27 October 2018

1 reference

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Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

27 October 2018

1 reference

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Dynamic multiphosphorylation passwords for activity-dependent gene expression

27 October 2018

1 reference

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10.1523/JNEUROSCI.1659-14.2014

27 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25319697 AND SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

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21 February 2020

PubMed publication ID

25319697

1 reference