PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes (Q34342465)

1 August 2017

title

PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes (English)

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1 August 2017

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Xaver Koenig

5

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Eva M Putz

Eva Maria Putz

1

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Michael Freissmuth

Michael Freissmuth

8

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Mathias Müller

Mathias Müller

9

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Hannes Stockinger

Hannes Stockinger

6

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author name string

Michaela Prchal-Murphy

2

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1 August 2017

Olivia Annabella Simma

3

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1 August 2017

Florian Forster

4

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1 August 2017

Roland P Piekorz

7

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1 August 2017

Veronika Sexl

10

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1 August 2017

Eva Zebedin-Brandl

11

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1 August 2017

language of work or name

English

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publication date

13 July 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

7

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1 August 2017

page(s)

e40852

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

13 July 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Inositol phospholipid signaling and the biology of natural killer cells

6 July 2018

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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

6 July 2018

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Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion

6 July 2018

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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

6 July 2018

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Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

6 July 2018

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Discovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

6 July 2018

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PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

6 July 2018

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Role of T-lymphocytes and pro-inflammatory mediators in the pathogenesis of chronic obstructive pulmonary disease.

6 July 2018

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Membrane fusion: grappling with SNARE and SM proteins

6 July 2018

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Targeted small-molecule inhibitors of protein kinase B as anticancer agents

6 July 2018

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Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance

6 July 2018

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The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

6 July 2018

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Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

6 July 2018

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Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance

6 July 2018

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Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy

6 July 2018

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Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

6 July 2018

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Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo

6 July 2018

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Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion.

6 July 2018

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T-cell homing specificity and plasticity: new concepts and future challenges

6 July 2018

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Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival

6 July 2018

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Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells

6 July 2018

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

6 July 2018

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Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

6 July 2018

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

6 July 2018

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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

6 July 2018

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Phosphoinositide 3-kinase in immunological systems

6 July 2018

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

6 July 2018

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Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

6 July 2018

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Patch-clamp techniques for time-resolved capacitance measurements in single cells

6 July 2018

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Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase

6 July 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0040852

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0040852

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0040852

The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0040852

PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4 CD25 Foxp3 regulatory T cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

Detection of T-cell degranulation: CD107a and b.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

p110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3396622

The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells

27 October 2018

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12 December 2020

Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation

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12 December 2020

p110δ is required for innate immunity to transplantable lymphomas

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12 December 2020

CD69 expression as an index of T-cell function: assay standardization, validation and use in monitoring immune recovery

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12 December 2020

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity

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12 December 2020

IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses

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12 December 2020

10.1371/JOURNAL.PONE.0040852

Identifiers

DOI

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1 August 2017

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1 August 2017

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