A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor (Q34342259)

1 August 2017

title

A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor (English)

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1 August 2017

6

David Piwnica-Worms

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1 August 2017

Adnan Elhammali

1

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1 August 2017

Joseph E Ippolito

2

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1 August 2017

Lynne Collins

3

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1 August 2017

Jan Crowley

4

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1 August 2017

Jayne Marasa

5

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1 August 2017

publication date

16 April 2014

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1 August 2017

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1 August 2017

volume

4

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1 August 2017

issue

7

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1 August 2017

page(s)

828-839

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

1 August 2017

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

6 July 2018

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Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate

6 July 2018

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6 July 2018

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

6 July 2018

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6 July 2018

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6 July 2018

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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

6 July 2018

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

6 July 2018

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

6 July 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

6 July 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

6 July 2018

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

6 July 2018

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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An enzymatic fluorimetric assay for glucose-6-phosphate: application in an in vitro Warburg-like effect

6 July 2018

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IDH1 and IDH2 mutations in gliomas

6 July 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

6 July 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

6 July 2018

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6 July 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

6 July 2018

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PDE5 inhibitors beyond erectile dysfunction

6 July 2018

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6 July 2018

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The relationship between effector binding and inhibition of activity in D-3-phosphoglycerate dehydrogenase

6 July 2018

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A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria

6 July 2018

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Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase

6 July 2018

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10.1158/2159-8290.CD-13-0572

27 October 2018

Identifiers

DOI

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1 August 2017

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1 August 2017

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