Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice (Q34338310)

1 August 2017

title

Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice (English)

1 reference

1 August 2017

0 references

Yoshiaki Kitaura

1

1 reference

1 August 2017

Hironori Hojo

2

1 reference

1 August 2017

Yuske Komiyama

3

1 reference

1 August 2017

Tsuyoshi Takato

4

1 reference

1 August 2017

Ung-il Chung

5

1 reference

1 August 2017

Shinsuke Ohba

6

1 reference

1 August 2017

language of work or name

English

0 references

publication date

14 October 2014

1 reference

1 August 2017

1 reference

1 August 2017

volume

9

1 reference

1 August 2017

issue

10

1 reference

1 August 2017

page(s)

e109597

1 reference

Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

14 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Sonic hedgehog regulates osteoblast function by focal adhesion kinase signaling in the process of fracture healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Constitutive activation of Gli2 impairs bone formation in postnatal growing mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Developmental regulation of the growth plate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Hedgehog signaling in animal development: paradigms and principles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Osteoblastic cells are involved in osteoclast formation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196929

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

6 July 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Impairment of bone healing by insulin receptor substrate-1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109597

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

21 January 2018

1 reference

12 December 2020

Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human

1 reference

12 December 2020

Periosteal cells are a major source of soft callus in bone fracture

1 reference

12 December 2020

Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function

1 reference

12 December 2020

Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand

1 reference

12 December 2020

Expression and distribution of transcripts for sonic hedgehog in the early phase of fracture repair

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0109597

Identifiers

DOI

1 reference

release_yj4o2hb4l5gjtm64smy6lue6y4

1 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yj4o2hb4l5gjtm64smy6lue6y4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4196929

1 reference

1 August 2017

1 reference