Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials (Q34325432)

1 August 2017

1 reference

title

Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials (English)

1 reference

1 August 2017

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Jae Ho Kim

1

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1 August 2017

Kenneth A Jenrow

series ordinal

2

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1 August 2017

Stephen L Brown

series ordinal

3

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1 August 2017

language of work or name

1 reference

30 September 2014

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Radiation oncology journal

1 August 2017

published in

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1 August 2017

volume

32

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1 August 2017

issue

3

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1 August 2017

page(s)

103-115

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 August 2017

copyright license

start time

1 January 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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6 July 2018

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Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus

6 July 2018

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Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34 cell populations based on global gene and microRNA expression signatures

6 July 2018

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6 July 2018

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6 July 2018

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Neurons born in the adult dentate gyrus form functional synapses with target cells

6 July 2018

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Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy

6 July 2018

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Directed differentiation of hippocampal stem/progenitor cells in the adult brain

6 July 2018

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Cellular and molecular mechanisms of fibrosis

6 July 2018

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Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

6 July 2018

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Successful mitigation of delayed intestinal radiation injury using pravastatin is not associated with acute injury improvement or tumor protection

6 July 2018

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Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain

6 July 2018

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6 July 2018

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Current management for late normal tissue injury: radiation-induced fibrosis and necrosis

6 July 2018

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6 July 2018

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6 July 2018

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Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.

6 July 2018

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Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands

6 July 2018

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Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells

6 July 2018

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6 July 2018

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Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity

6 July 2018

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Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

6 July 2018

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Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor

6 July 2018

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Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis.

6 July 2018

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Vasculogenesis and angiogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Extreme sensitivity of adult neurogenesis to low doses of X-irradiation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Normal tissue radiobiology: from the laboratory to the clinic.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Time-dependent inhibition of pan-inflammatory cytokines mitigates radiation-induced skin injury in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Inhibition of Smad3 expression in radiation-induced fibrosis using a novel method for topical transcutaneous gene therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Combined atorvastatin and ramipril mitigate radiation-induced impairment of dentate gyrus neurogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

No significant endothelial apoptosis in the radiation-induced gastrointestinal syndrome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Effect of bevacizumab on radiation necrosis of the brain

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Depletion of neural precursor cells after local brain irradiation is due to radiation dose to the parenchyma, not the vasculature.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

A role for adult neurogenesis in spatial long-term memory.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Statins promote potent systemic antioxidant effects through specific inflammatory pathways

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Relation of inflammation and benefit of statins after percutaneous coronary interventions

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Hypoxia in radiation-induced blood-spinal cord barrier breakdown.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Further evidence for oxidant-induced vascular endothelial growth factor up-regulation in the bronchoalveolar lavage fluid of lung cancer patients undergoing radio-chemotherapy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194292

Treatment of radiation nephropathy with ACE inhibitors

28 October 2018

1 reference

12 December 2020

Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial

1 reference

12 December 2020

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

1 reference

12 December 2020

Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme

1 reference

12 December 2020

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation 1

1 reference

12 December 2020

Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy

1 reference

12 December 2020

Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure

1 reference

12 December 2020

Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study

1 reference

12 December 2020

Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases

1 reference

12 December 2020

Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side-effects after radiation therapy and as countermeasure against radiation exposure

1 reference

12 December 2020

Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist

1 reference

12 December 2020

Plerixafor, a CXCR4 antagonist, mitigates skin radiation-induced injury in mice

1 reference

12 December 2020

Effect of recombinant human keratinocyte growth factor (Δ23rHuKGF, Palifermin) on inflammatory and immune changes in mouse tongue during fractionated irradiation

1 reference

12 December 2020

Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time

1 reference

12 December 2020

Recruitment of Gr1( )CD11b ( )F4/80 ( ) population in the bone marrow and spleen by irradiation-induced pulmonary damage

1 reference

12 December 2020

Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts

1 reference

12 December 2020

10.3857/ROJ.2014.32.3.103

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference