The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism (Q34324047)

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English	The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

lipopolysaccharide

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Adam D Bachstetter

object named as

Adam D Bachstetter

1

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Linda J Van Eldik

3

object named as

Linda J Van Eldik

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Bin Xing

2

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Europe PubMed Central

PubMed publication ID

1 August 2017

publication date

10 October 2014

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Europe PubMed Central

PubMed publication ID

1 August 2017

Journal of Neuroinflammation

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Europe PubMed Central

PubMed publication ID

1 August 2017

11

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Europe PubMed Central

PubMed publication ID

1 August 2017

175

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

copyright license

Creative Commons Attribution 4.0 International

10 October 2014

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April 2022 Public Data File from Crossref

copyright status

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Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

1 reference

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1 reference

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1 reference

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The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

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MSK activation and physiological roles

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats.

1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://api.crossref.org/works/10.1186/S12974-014-0175-6

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4193976

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25297465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25297465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12974-014-0175-6

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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