Protein tyrosine phosphatases: prospects for therapeutics (Q34318066)

1 August 2017

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title

Protein tyrosine phosphatases: prospects for therapeutics (English)

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1 August 2017

Zhang ZY

1

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1 August 2017

publication date

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

published in

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1 August 2017

volume

5

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1 August 2017

issue

4

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1 August 2017

page(s)

416-423

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Signaling--2000 and beyond

1 August 2017

cites work

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Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases.

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Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis

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An RNA 5'-triphosphatase related to the protein tyrosine phosphatases

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

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The multiple roles of PTEN in tumor suppression

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate

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Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway

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Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy

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Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes

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7 January 2021

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant

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A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium

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The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.

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7 January 2021

Regulation of Insulin Action by Protein Tyrosine Phosphatases

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Protein tyrosine phosphatases: their role in insulin action and potential as drug targets.

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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7 January 2021

Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

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7 January 2021

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

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7 January 2021

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

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7 January 2021

CDC25 phosphatases as potential human oncogenes

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Role of the Cdc25A phosphatase in human breast cancer

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7 January 2021

Cdc25 as a potential target of anticancer agents.

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7 January 2021

FAP-1: a protein tyrosine phosphatase that associates with Fas

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7 January 2021

Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1

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7 January 2021

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

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Prevention and reversal of renal allograft rejection by antibody against CD45RB

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7 January 2021

A neuronal protein tyrosine phosphatase induced by nerve growth factor

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7 January 2021

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

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7 January 2021

Dual specificity phosphatases: a gene family for control of MAP kinase function.

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7 January 2021

Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth

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7 January 2021

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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7 January 2021

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

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7 January 2021

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

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7 January 2021

Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1

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7 January 2021

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

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7 January 2021

Structure, mechanism, and specificity of protein-tyrosine phosphatases

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7 January 2021

Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning"

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7 January 2021

Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery

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7 January 2021

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

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7 January 2021

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

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7 January 2021

Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B

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7 January 2021

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

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7 January 2021

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

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7 January 2021

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

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7 January 2021

[Difluro(phosphono)methyl]phenylalanine-containing peptide inhibitors of protein tyrosine phosphatases

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7 January 2021

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

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7 January 2021

The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling

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7 January 2021

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

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7 January 2021

Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

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7 January 2021

Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

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7 January 2021

10.1016/S1367-5931(00)00223-4

Identifiers

DOI

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1 August 2017

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