Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue (Q34312182)

1 August 2017

title

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue (English)

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1 August 2017

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Hindrik Mulder

6

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Dean Sherry

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ORCID Public Data File 2021

author name string

Anne Boucher

1

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1 August 2017

Danhong Lu

2

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1 August 2017

Shawn C Burgess

3

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1 August 2017

Sabine Telemaque-Potts

4

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1 August 2017

Mette V Jensen

5

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1 August 2017

May-Yun Wang

7

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1 August 2017

Roger H Unger

8

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1 August 2017

A Dean Sherry

9

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1 August 2017

Christopher B Newgard

10

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1 August 2017

language of work or name

English

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publication date

7 April 2004

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Journal of Biological Chemistry

1 August 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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1 August 2017

volume

279

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issue

26

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1 August 2017

page(s)

27263-27271

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Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

1 August 2017

cites work

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Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

21 January 2018

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Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

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Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids

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Isolation of INS-1-derived cell lines with robust ATP-sensitive K channel-dependent and -independent glucose-stimulated insulin secretion

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Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

21 January 2018

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

21 January 2018

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

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OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

21 January 2018

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Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.

21 January 2018

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STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

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Continuous measurement of oxygen consumption by pancreatic islets

21 January 2018

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Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT).

21 January 2018

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Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

21 January 2018

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Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

21 January 2018

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Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats

21 January 2018

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Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase

21 January 2018

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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

21 January 2018

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

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Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets

21 January 2018

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Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity

21 January 2018

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Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content

21 January 2018

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Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity

21 January 2018

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

21 January 2018

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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

21 January 2018

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Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

21 January 2018

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Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells

21 January 2018

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Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

21 January 2018

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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

21 January 2018

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Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

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The subcellular localization of acetyl-CoA carboxylase 2

21 January 2018

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Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M401167200

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1 August 2017

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