A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia (Q34310547)

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8 February 2020

title

A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia (English)

1 reference

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8 February 2020

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acute promyelocytic leukemia

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1

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8 February 2020

Nicole R Grieselhuber

4

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8 February 2020

author name string

Andrew A Lane

2

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8 February 2020

John S Welch

3

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8 February 2020

Jacqueline E Payton

5

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8 February 2020

Timothy J Ley

6

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8 February 2020

language of work or name

English

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publication date

20 July 2010

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8 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20647568 AND SRC:MED&resulttype=core&format=json

8 February 2020

volume

116

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issue

18

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8 February 2020

page(s)

3604-3610

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describes a project that uses

8 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2981479/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

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Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip

6 July 2018

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Commonly dysregulated genes in murine APL cells

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The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy

6 July 2018

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Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.

6 July 2018

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Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells

6 July 2018

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Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice

6 July 2018

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Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

6 July 2018

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

6 July 2018

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STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation

6 July 2018

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BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

6 July 2018

1 reference

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Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

6 July 2018

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

6 July 2018

1 reference

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Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae

6 July 2018

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Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation

6 July 2018

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Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

6 July 2018

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High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

28 October 2018

1 reference

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Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia

28 October 2018

1 reference

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Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences

28 October 2018

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12 December 2020

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

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12 December 2020

Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

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12 December 2020

Mouse models of acute promyelocytic leukemia

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12 December 2020

10.1182/BLOOD-2008-11-189282

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20647568 AND SRC:MED&resulttype=core&format=json

release_q3ajd42d7zglbpbngvq75nm2py

8 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q3ajd42d7zglbpbngvq75nm2py

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20647568 AND SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

20647568

1 reference