The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling (Q34304678)

1 August 2017

title

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling (English)

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1 August 2017

7

Angel F Lopez

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1 August 2017

Urmi Dhagat

2

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Michael W Parker

object named as

Michael W Parker

8

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Claudine S. Bonder

6

object named as

Claudine S Bonder

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1 August 2017

Sophie E Broughton

1

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1 August 2017

Timothy R Hercus

3

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1 August 2017

Tracy L Nero

4

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1 August 2017

Michele A Grimbaldeston

5

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1 August 2017

publication date

1 November 2012

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1 August 2017

published in

Immunological Reviews

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1 August 2017

volume

250

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1 August 2017

issue

1

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1 August 2017

page(s)

277-302

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The GM-CSF receptor family: mechanism of activation and implications for disease

1 August 2017

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Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

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The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

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Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF).

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Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

21 January 2018

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Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction

21 January 2018

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Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis

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Dendritic cells: specialized and regulated antigen processing machines

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Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice

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Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia

21 January 2018

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Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia.

21 January 2018

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

21 January 2018

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Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates

21 January 2018

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Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.

21 January 2018

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Deoxyribonucleic acid triplex formation inhibits granulocyte macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells

21 January 2018

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Nf1 and Gmcsf interact in myeloid leukemogenesis

21 January 2018

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Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

21 January 2018

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Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

21 January 2018

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Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

21 January 2018

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Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal

21 January 2018

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Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.

21 January 2018

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21 January 2018

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Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan

21 January 2018

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Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy

21 January 2018

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Long-term follow-up and treatment of congenital alveolar proteinosis

21 January 2018

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Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB

21 January 2018

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Hereditary pulmonary alveolar proteinosis caused by recessiveCSF2RBmutations

21 January 2018

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IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

21 January 2018

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Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via phosphatidylinositol 3-kinase- and hydrogen peroxide-dependent mechanisms

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

21 January 2018

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Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor

21 January 2018

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Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

21 January 2018

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The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

21 January 2018

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Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration

21 January 2018

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An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope

21 January 2018

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Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

21 January 2018

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Rational design of a mouse granulocyte macrophage-colony-stimulating factor receptor antagonist

21 January 2018

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The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation

21 January 2018

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Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

21 January 2018

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Structural basis of interleukin-5 dimer recognition by its α receptor

21 January 2018

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Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Rα

21 January 2018

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A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode

21 January 2018

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Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

21 January 2018

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Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly

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Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

21 January 2018

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Specific human granulocyte-macrophage colony-stimulating factor antagonists.

21 January 2018

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A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

21 January 2018

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Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

21 January 2018

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Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

21 January 2018

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Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

21 January 2018

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Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

21 January 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

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21 January 2018

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Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

21 January 2018

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Interleukin 3 stimulates proliferation and triggers endothelial-leukocyte adhesion molecule 1 gene activation of human endothelial cells

21 January 2018

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The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration

21 January 2018

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Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis

21 January 2018

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Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release

21 January 2018

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Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.

21 January 2018

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Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

21 January 2018

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Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3.

21 January 2018

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Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease

21 January 2018

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Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4 and CD8 T cell lines in atopics asthmatics, and atopic and nonatopic controls

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

The role of human mast cell-derived cytokines in eosinophil biology

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

21 January 2018

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Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3

21 January 2018

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Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

21 January 2018

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Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family

21 January 2018

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Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex

21 January 2018

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Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family

21 January 2018

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A human interleukin 3 analog with increased biological and binding activities

21 January 2018

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A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.

21 January 2018

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The Receptor Binding Site of Human Interleukin-3 Defined by Mutagenesis and Molecular Modeling

21 January 2018

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Saturation mutagenesis of human interleukin-3.

21 January 2018

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Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

21 January 2018

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Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains

21 January 2018

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Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Recombinant human interleukin 5 is a selective activator of human eosinophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Enhancement of human basophil histamine release by interleukin 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

21 January 2018

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Treatment of patients with the hypereosinophilic syndrome with mepolizumab

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mepolizumab and exacerbations of refractory eosinophilic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

The Three-Dimensional Structure of Human Interleukin-5 at 2.4-Angstroms Resolution: Implication for the Structures of Other Cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

21 January 2018

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Molecular cloning and expression of the human interleukin 5 receptor

21 January 2018

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Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes

21 January 2018

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Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imaging

21 January 2018

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Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition

21 January 2018

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Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Analysis of the interaction between human interleukin-5 and the soluble domain of its receptor using a surface plasmon resonance biosensor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Randomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Recruitment pharmacophore for interleukin 5 receptor alpha antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Receptor epitope usage by an interleukin-5 mimetic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Cytokine receptor activation at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Identification of mast cell progenitors in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Hematopoietic stem cell: self-renewal versus differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Complex interactions in EML cell stimulation by stem cell factor and IL-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

MHC class II-dependent basophil-CD4 T cell interactions promote T(H)2 cytokine-dependent immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin: A Hormone with Multiple Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Nonerythropoietic roles of erythropoietin in the fetus and neonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Recombinant human erythropoietin influences revascularization and healing in a rat model of random ischaemic flaps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Beneficial effects of carbamylated erythropoeitin on trauma-induced brain edema: Proposed molecular mechanisms of action*

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin and VEGF exhibit equal angiogenic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin enhances hippocampal response during memory retrieval in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

NMR structure of human erythropoietin and a comparison with its receptor bound conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Derivatives of erythropoietin that are tissue protective but not erythropoietic

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Interleukin 3 promotes erythroid burst formation in "serum-free" cultures without detectable erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin regulates endothelial progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Isolation of putative progenitor endothelial cells for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01164.X

10.1111/J.1600-065X.2012.01164.X

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference