A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells (Q34302726)

1 August 2017

title

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells (English)

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1 August 2017

Joelle D Sacks

7

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ORCID Public Data File 2021

author name string

Sarah K Knutson

1

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1 August 2017

Tim J Wigle

2

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1 August 2017

Natalie M Warholic

3

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1 August 2017

Christopher J Sneeringer

4

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1 August 2017

Christina J Allain

5

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1 August 2017

Christine R Klaus

6

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1 August 2017

Alejandra Raimondi

8

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1 August 2017

Christina R Majer

9

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1 August 2017

Jeffrey Song

10

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1 August 2017

Margaret Porter Scott

11

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1 August 2017

Lei Jin

12

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1 August 2017

Jesse J Smith

13

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1 August 2017

Edward J Olhava

14

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1 August 2017

Richard Chesworth

15

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1 August 2017

Mikel P Moyer

16

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1 August 2017

Victoria M Richon

17

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1 August 2017

Robert A Copeland

18

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1 August 2017

Heike Keilhack

19

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1 August 2017

Roy M Pollock

20

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1 August 2017

Kevin W Kuntz

21

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1 August 2017

language of work or name

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30 September 2012

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1 August 2017

published in

Nature Chemical Biology

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1 August 2017

volume

8

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1 August 2017

issue

11

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1 August 2017

page(s)

890-896

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

A histone H3 lysine 27 demethylase regulates animal posterior development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Structural basis of EZH2 recognition by EED

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Chemogenetic analysis of human protein methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

How many mutations are required for tumorigenesis? Implications from human cancer data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Choosing anticancer drug targets in the postgenomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Protein methyltransferases as a target class for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1084

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23023262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

STUDIES ON LIVER ALCOHOL HYDROGENASE COMPLEXES. 3. MULTIPLE INHIBITION KINETICS IN THE PRESENCE OF TWO COMPETITIVE INHIBITORS

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23023262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1084

1 reference

Dimensions Publication ID

1 August 2017

1024506073

0 references

1 reference