Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes (Q34302721)

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title

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes (English)

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Carolina E Hagberg

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Daniel Nyqvist

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Daniel Nyqvist

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author name string

Annika Mehlem

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Annelie Falkevall

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Lars Muhl

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Barbara C Fam

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Henrik Ortsäter

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Pierre Scotney

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Erik Samén

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Li Lu

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Sharon Stone-Elander

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Joseph Proietto

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Sofianos Andrikopoulos

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Ake Sjöholm

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Andrew Nash

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Ulf Eriksson

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language of work or name

English

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publication date

26 September 2012

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volume

490

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issue

7420

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page(s)

426-430

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The Diabetes Prevention Program (DPP): description of lifestyle intervention

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cites work

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

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Vascular endothelial growth factor B controls endothelial fatty acid uptake.

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Global and societal implications of the diabetes epidemic

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Targeting ceramide synthesis to reverse insulin resistance.

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SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity

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RETRACTED: The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes

21 January 2018

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Metabolism and vascular fatty acid transport

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Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms

21 January 2018

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Vascular endothelial growth factor B, a novel growth factor for endothelial cells

21 January 2018

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Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis

21 January 2018

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Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

21 January 2018

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Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1

21 January 2018

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Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy

21 January 2018

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Insulin resistance in genetically obese, hyperglycemic mice.

21 January 2018

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A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

21 January 2018

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

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The metabolic syndrome

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Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies

21 January 2018

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The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

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Review article: Thiazolidinediones and heart failure

21 January 2018

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Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

21 January 2018

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Evaluating the glucose tolerance test in mice

21 January 2018

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A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion

21 January 2018

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Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice

21 January 2018

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Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts

21 January 2018

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Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice

21 January 2018

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Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

21 January 2018

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Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver

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Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats

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Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

21 January 2018

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12 December 2020

The feto-placental glucose steal phenomenon is a major cause of maternal metabolic adaptation during late pregnancy in the rat

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12 December 2020

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat

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12 December 2020

Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats

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12 December 2020

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

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12 December 2020

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

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12 December 2020

Identifiers

DOI

10.1038/NATURE11464

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1 August 2017

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