Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes (Q34292432)

1 August 2017

title

Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes (English)

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1 August 2017

Amy Willis

1

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1 August 2017

Eun Joo Jung

series ordinal

2

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1 August 2017

Therese Wakefield

series ordinal

3

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1 August 2017

Xinbin Chen

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

1 March 2004

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1 August 2017

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1 August 2017

volume

23

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1 August 2017

issue

13

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1 August 2017

page(s)

2330-2338

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p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

1 August 2017

cites work

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Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome

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p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

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Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle

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In vitro analysis of the dominant negative effect of p53 mutants

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Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations.

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Gain of function mutations in p53.

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p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

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WAF1, a potential mediator of p53 tumor suppression

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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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Molecular basis for heterogeneity of the human p53 protein

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Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

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Oncogenic forms of p53 inhibit p53-regulated gene expression

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p53: puzzle and paradigm

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The p53 tumour suppressor gene

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The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

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High metastatic potential in mice inheriting a targeted p53 missense mutation

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

21 January 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

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Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

21 January 2018

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Kinetics of p53 binding to promoter sites in vivo

21 January 2018

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p53 modulation of TFIIH–associated nucleotide excision repair activity

21 January 2018

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p73 can suppress the proliferation of cells that express mutant p53.

21 January 2018

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Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

21 January 2018

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Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207396

inferred from DOI database lookup

7 January 2021

based on heuristic

Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207396

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1207396

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Dimensions Publication ID

1 August 2017

1023930052

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