Molecular and cellular mechanisms of general anaesthesia (Q34291163)

1 August 2017

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title

Molecular and cellular mechanisms of general anaesthesia (English)

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1 August 2017

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N P Franks

1

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1 August 2017

W R Lieb

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

1 February 1994

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1 August 2017

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1 August 2017

volume

367

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1 August 2017

issue

6464

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1 August 2017

page(s)

607-614

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The actions of neutral anaesthetics on ion conductances of nerve membranes

1 August 2017

cites work

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7 January 2021

The actions of some general anaesthetics on the potassium current of the squid giant axon

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7 January 2021

Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila

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7 January 2021

Selective effects of volatile general anesthetics on identified neurons.

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7 January 2021

The effect of aliphatic alcohols on the transient potassium current in hippocampal neurones

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7 January 2021

Changes in spontaneous firing patterns of rat hippocampal neurones induced by volatile anaesthetics.

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7 January 2021

A role for changes in axonal excitability in general anesthesia

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7 January 2021

Different types of calcium channels mediate central synaptic transmission

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7 January 2021

Selective actions of volatile general anaesthetics at molecular and cellular levels

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7 January 2021

Halothane blocks low-voltage-activated calcium current in rat sensory neurons

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7 January 2021

Accelerating effects of pentobarbitone on the inactivation process of the calcium current in Helix neurones

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7 January 2021

Halothane suppresses slow inward currents in hippocampal slices.

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7 January 2021

Augmentation by calcium channel antagonists of general anaesthetic potency in mice

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7 January 2021

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine.

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7 January 2021

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

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7 January 2021

Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons

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7 January 2021

Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat

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7 January 2021

The noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

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7 January 2021

Use-dependent pentobarbital block of kainate and quisqualate currents

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7 January 2021

Ethanol inhibits NMDA-activated ion current in hippocampal neurons

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7 January 2021

Action of enflurane on cholinergic transmission in identified Aplysia neurones

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7 January 2021

Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels

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7 January 2021

Postsynaptic effect of i.v. anaesthetic agents at the neuromuscular junction.

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7 January 2021

Effects of pentobarbitone on acetylcholine-activated channels in mammalian muscle

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7 January 2021

Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor

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7 January 2021

The effects of alcohols and diols at the nicotinic acetylcholine receptor of the neuromuscular junction

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7 January 2021

Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes

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7 January 2021

Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes.

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7 January 2021

Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus

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7 January 2021

Two mechanisms for anesthetic-induced enhancement of GABAA-mediated neuronal inhibition

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7 January 2021

Pentobarbital: stereospecific actions of ( ) and (-) isomers revealed on cultured mammalian neurons

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7 January 2021

General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons.

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7 January 2021

Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics

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7 January 2021

Molecular Determinants of General Anesthetic Action: Role of GABAA Receptor Structure

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7 January 2021

Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons.

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7 January 2021

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

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7 January 2021

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

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7 January 2021

Modulation of GABAA receptor activity by alphaxalone

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7 January 2021

General Anesthetic Action on ?-Aminobutyric Acid?Activated Channels

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7 January 2021

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture

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7 January 2021

Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro.

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7 January 2021

Anaesthetic depression of excitatory synaptic transmission in neocortex.

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7 January 2021

Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit

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7 January 2021

Volatile general anaesthetics activate a novel neuronal K current

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7 January 2021

Isoflurane anesthesia is stereoselective.

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7 January 2021

Investigations into the origin of the high pressure neurological syndrome: the interaction between pressure, strychnine and 1,2-propandiols in the mouse

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7 January 2021

Species variation and the mechanism of pressure–anaesthetic interactions

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7 January 2021

Actions and interactions of high pressure and general anaesthetics

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7 January 2021

Molecular mechanisms of general anaesthesia

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7 January 2021

Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal

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7 January 2021

Steady-state catecholamine distribution in chromaffin granule preparations: a test of the pump-leak hypothesis of general anesthesia

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7 January 2021

Release of endogenous amino acid neurotransmitter candidates from rat olfactory cortex slices: possible regulatory mechanisms and the effects of pentobarbitone

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7 January 2021

The effect of anaesthetics on the uptake and release of gamma-aminobutyrate and D-aspartate in rat brain slices

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7 January 2021

The effects of anaesthetics on the uptake and release of amino acid neurotransmitters in thalamic slices

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7 January 2021

Clinical concentrations of volatile anesthetics reduce depolarization-evoked release of [3H]norepinephrine, but not [3H]acetylcholine, from rat cerebral cortex.

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7 January 2021

Mechanisms of halothane action on synaptic transmission in motoneurons of the newborn rat spinal cord in vitro.

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7 January 2021

Reduction by general anaesthetics of group Ia excitatory postsynaptic potentials and currents in the cat spinal cord

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7 January 2021

The action of volatile anaesthetics on stimulus-secretion coupling in bovine adrenal chromaffin cells

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7 January 2021

Effects of Volatile Anesthetics on Cytoplasmic Ca2 Signaling and Transmitter Release in a Neural Cell Line

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7 January 2021

The action of halothane on stimulus-secretion coupling in clonal (GH3) pituitary cells

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7 January 2021

Evidence that barbiturates inhibit antigen-induced responses through interactions with a GTP-binding protein in rat basophilic leukemia (RBL-2H3) cells.

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7 January 2021

Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes

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7 January 2021

Inhibition of protein kinase C by alcohols and anaesthetics

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7 January 2021

General anesthetics inhibit cytochrome P450 monooxygenases and arachidonic acid metabolism.

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7 January 2021

Depression of cerebellar cGMP by barbiturates Relationship to locomotor activity

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7 January 2021

Correlation of general anesthetic potency with solubility in membranes

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7 January 2021

What is the molecular nature of general anaesthetic target sites?

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7 January 2021

Is the mechanism of general anesthesia related to lipid membrane spontaneous curvature?

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7 January 2021

Transbilayer effects of ethanol on fluidity of brain membrane leaflets.

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7 January 2021

Effects of non-electrolyte molecules with anesthetic activity on the physical properties of DMPC multilamellar liposomes.

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7 January 2021

Nature of alcohol and anesthetic action on cooperative membrane equilibria

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7 January 2021

The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.

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7 January 2021

Do general anaesthetics act by competitive binding to specific receptors?

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7 January 2021

Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase.

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7 January 2021

The inhibition of a membrane-bound enzyme as a model for anaesthetic action and drug toxicity

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7 January 2021

Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity.

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7 January 2021

Saturable binding of halothane to rat brain synaptosomes

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7 January 2021

Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site

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7 January 2021

Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects

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7 January 2021

Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia

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7 January 2021

Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids

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7 January 2021

Anesthetic cutoff in cycloalkanemethanols. A test of current theories.

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7 January 2021

Mechanism of anesthesia: Anesthetics may restructure the hydrogen belts of membranes

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7 January 2021

Dehydration: a new alcohol theory

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7 January 2021

Alcohols dehydrate lipid membranes: an infrared study on hydrogen bonding

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7 January 2021

Role of hydrogen bonding in general anesthesia.

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7 January 2021

Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase

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7 January 2021

Thiopental pharmacodynamics. II. Quantitation of clinical and electroencephalographic depth of anesthesia

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7 January 2021

The role of metabolism and protein binding in thiopental anesthesia.

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7 January 2021

Distribution of pentobarbital and diphenylhydantoin between plasma and cells in blood: effect of salicylic acid, temperature and total drug concentration

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7 January 2021

Pharmacokinetic evaluation of ICI 35 868 in man. Single induction doses with different rates of injection

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7 January 2021

Pharmacokinetics and protein binding of propofol in patients with cirrhosis.

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7 January 2021

The pharmacokinetics of propofol in laboratory animals

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7 January 2021

Structural specificity of barbiturates and related drugs.

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7 January 2021

Barbiturates: Their in vivo effects and potential biochemical mechanisms

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7 January 2021

Comparative pharmacology of the optical isomers of ketamine in mice

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7 January 2021

Comparative pharmacology of the ketamine isomers. Studies in volunteers

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7 January 2021

Unequal Anaesthetic Potency Despite Equal Brain Concentration of Hexobarbital Antipodes

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7 January 2021

Halothane inhibits two components of calcium current in clonal (GH3) pituitary cells

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7 January 2021

Identifiers

DOI

10.1038/367607A0

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1 August 2017

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