The unfolded protein response and Alzheimer's disease (Q34282281)

1 August 2017

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title

The unfolded protein response and Alzheimer's disease (English)

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1 August 2017

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K Imaizumi

1

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1 August 2017

K Miyoshi

2

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1 August 2017

T Katayama

3

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1 August 2017

T Yoneda

4

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1 August 2017

M Taniguchi

5

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1 August 2017

T Kudo

6

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1 August 2017

M Tohyama

7

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1 August 2017

language of work or name

English

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publication date

1 May 2001

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Biochimica et Biophysica Acta

1 August 2017

published in

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1 August 2017

volume

1536

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1 August 2017

issue

2-3

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1 August 2017

page(s)

85-96

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 August 2017

cites work

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Defective protein folding as a basis of human disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Conformational disease

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Endoplasmicreticulum-induced signal transduction and gene expression

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The unfolded protein response: an intracellular signalling pathway with many surprising features

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Tripartite management of unfolded proteins in the endoplasmic reticulum

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Immunoglobulin heavy chain binding protein

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A transmembrane protein with a cdc2 /CDC28-related kinase activity is required for signaling from the ER to the nucleus

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Are cerebrovascular factors involved in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Presenilin and the UPR

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50049-7

7 January 2021

10.1016/S0925-4439(01)00049-7

Identifiers

DOI

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1 August 2017

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