HIV elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses (Q34275430)

1 August 2017

title

HIV elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses (English)

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1 August 2017

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4

Marion C Lanteri

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1 August 2017

8

Steven G Deeks

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1 August 2017

Rachel E Owen

1

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1 August 2017

John W Heitman

2

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1 August 2017

Dale F Hirschkorn

3

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1 August 2017

Hope H Biswas

5

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1 August 2017

Jeffrey N Martin

6

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1 August 2017

Melissa R Krone

7

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1 August 2017

Philip J Norris

9

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1 August 2017

NIAID Center for HIV/AIDS Vaccine Immunology

10

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1 August 2017

language of work or name

English

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publication date

1 May 2010

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1 August 2017

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1 August 2017

volume

24

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1 August 2017

issue

8

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1 August 2017

page(s)

1095-1105

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Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

1 August 2017

cites work

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Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control

6 July 2018

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HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells

6 July 2018

1 reference

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The effect of aging on T-regulatory cell frequency in HIV infection

6 July 2018

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Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy

6 July 2018

1 reference

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Preservation of FoxP3 regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4 T-cell activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

FoxP3 CD4 regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo

6 July 2018

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Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8 T cells

6 July 2018

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Relationship between T cell activation and CD4 T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

6 July 2018

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Severe depletion of CD4 CD25 regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

The dynamic co-evolution of memory and regulatory CD4 T cells in the periphery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 T reg cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8 T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

A peripheral circulating compartment of natural naive CD4 Tregs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Naturally arising Foxp3-expressing CD25 CD4 regulatory T cells in immunological tolerance to self and non-self

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Depletion of regulatory T cells in HIV infection is associated with immune activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

T cell activation in HIV-seropositive Ugandans: differential associations with viral load, CD4 T cell depletion, and coinfection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Regulatory T cells and mechanisms of immune system control

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

CD4 CD25 T cells regulate virus-specific primary and memory CD8 T cell responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Foxp3 programs the development and function of CD4 CD25 regulatory T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Analysis of total human immunodeficiency virus (HIV)-specific CD4( ) and CD8( ) T-cell responses: relationship to viral load in untreated HIV infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Immunologic self-tolerance maintained by CD25( )CD4( ) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Selective increase of activation antigens HLA-DR and CD38 on CD4 CD45RO T lymphocytes during HIV-1 infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4 T helper cell depletion occurs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Regulatory T cells in human immunodeficiency virus-infected patients are elevated and independent of immunological and virological status, as well as initiation of highly active anti-retroviral therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

The relationship of T-regulatory cell subsets to disease stage, immune activation, and pathogen-specific immunity in HIV infection

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Redistribution of FOXP3-positive regulatory T cells from lymphoid tissues to peripheral blood in HIV-infected patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

FOXP3 expressing CD127lo CD4 T cells inversely correlate with CD38 CD8 T cell activation levels in primary HIV-1 infection

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Human CD4 regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Low CD4 T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4 T-cell activation and senescence but not with lower effector memory T-cell function

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4 T cells under successful highly active antiretroviral therapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Human immunodeficiency virus-driven expansion of CD4 CD25 regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

CD4 CD25high regulatory cells in human peripheral blood

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

Twenty-first century Foxp3

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972651

CD38 CD8 T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals

28 October 2018

1 reference

12 December 2020

The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8 T cells in HIV-1-infected typical progressors, but not in long-term non-progressors

1 reference

12 December 2020

Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals

1 reference

12 December 2020

Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

1 reference

12 December 2020

TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients

1 reference

12 December 2020

Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry

1 reference

12 December 2020

Elevated CD38 antigen expression on CD8 T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 cell count, soluble immune activation markers, or combinations of

1 reference

12 December 2020

Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4 T cells from HIV-infected patients responding to antiretroviral therapy

1 reference

12 December 2020

Relationship between CD38 expression on peripheral blood T-cells and monocytes, and response to antiretroviral therapy: a one-year longitudinal study of a cohort of chronically infected ART-naive HIV-1 patients

1 reference

12 December 2020

Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection

1 reference

12 December 2020

10.1097/QAD.0B013E3283377A1E

Identifiers

DOI

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1 August 2017

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1 August 2017

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