The emerging role of CXC chemokines and their receptors in cancer (Q34263645)

1 August 2017

title

The emerging role of CXC chemokines and their receptors in cancer (English)

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1 August 2017

Victoria Vinader

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1 August 2017

Kamyar Afarinkia

series ordinal

2

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1 August 2017

publication date

1 May 2012

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Future Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

4

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1 August 2017

issue

7

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1 August 2017

page(s)

853-867

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A role for CXCR2 in senescence, but what about in cancer?

1 August 2017

cites work

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Control of senescence by CXCR2 and its ligands

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Chemokine network in the nervous system: a new target for pain relief.

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Chemokines and pain mechanisms.

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Chemokine signaling and the management of neuropathic pain

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Chemokines and chemokine receptors: new insights into cancer-related inflammation.

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The many roles of chemokines and chemokine receptors in inflammation

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How microorganisms avoid phagocyte attraction

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Chemokine coreceptor signaling in HIV-1 infection and pathogenesis

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Cancer and the chemokine network

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Role of chemokines in tumor growth

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Manipulating the chemokine-chemokine receptor network to treat cancer

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The chemokine system in cancer biology and therapy

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Chemokines: agents for the immunotherapy of cancer?

21 January 2018

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Chemokine-chemokine receptors in cancer immunotherapy

21 January 2018

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Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

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Chemokine modulation of the tumor microenvironment

21 January 2018

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The role of chemokines in cancer immune surveillance by the adaptive immune system.

21 January 2018

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Tumor immune escape by the loss of homeostatic chemokine expression.

21 January 2018

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21 January 2018

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Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer

21 January 2018

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Interleukin-8/CXCL8 is a growth factor for human lung cancer cells

21 January 2018

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Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.

21 January 2018

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Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

21 January 2018

1 reference

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

21 January 2018

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The Crosstalk Between the Matrix Metalloprotease System and the Chemokine Network in Acute Myeloid Leukemia

21 January 2018

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Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis.

21 January 2018

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Cancer CXC chemokine networks and tumour angiogenesis

21 January 2018

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CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection.

21 January 2018

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Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

21 January 2018

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Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.

21 January 2018

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Elevated expression of CXC chemokines in pediatric osteosarcoma patients

21 January 2018

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CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis

21 January 2018

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CXCL5 overexpression is associated with late stage gastric cancer.

21 January 2018

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Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer.

21 January 2018

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ELR CXC chemokine expression in benign and malignant colorectal conditions

21 January 2018

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Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis

21 January 2018

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Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma.

21 January 2018

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The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma

21 January 2018

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GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1.

21 January 2018

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CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer

21 January 2018

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Overexpression of CXCL5 Is Associated With Poor Survival in Patients With Pancreatic Cancer

21 January 2018

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CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

21 January 2018

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Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines

21 January 2018

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The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue

21 January 2018

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CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer

21 January 2018

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Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis

21 January 2018

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Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer

21 January 2018

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Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma

21 January 2018

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Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis

21 January 2018

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Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis

21 January 2018

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CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth

21 January 2018

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Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α.

21 January 2018

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Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy

21 January 2018

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Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models.

21 January 2018

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CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion

21 January 2018

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CXCL8 and its cognate receptors in melanoma progression and metastasis

21 January 2018

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Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.

21 January 2018

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Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma

21 January 2018

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CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

21 January 2018

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

21 January 2018

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The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor

21 January 2018

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QSAR models for CXCR2 receptor antagonists based on the genetic algorithm for data preprocessing prior to application of the PLS linear regression method and design of the new compounds using in silico virtual screening.

21 January 2018

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Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor

21 January 2018

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Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases

21 January 2018

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Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists

21 January 2018

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists

21 January 2018

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CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis

21 January 2018

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Role of CXCR3 Ligands in IL-7/IL-7Rα-Fc–Mediated Antitumor Activity in Lung Cancer

21 January 2018

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TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines

21 January 2018

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CXCR3 ligands: redundant, collaborative and antagonistic functions

21 January 2018

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Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma

21 January 2018

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Dysregulation of secretion of CXC alpha-chemokine CXCL10 in papillary thyroid cancer: modulation by peroxisome proliferator-activated receptor-gamma agonists.

21 January 2018

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CXCR3-B Can Mediate Growth-inhibitory Signals in Human Renal Cancer Cells by Down-regulating the Expression of Heme Oxygenase-1

21 January 2018

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Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression.

21 January 2018

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Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer

21 January 2018

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CXCR3-B expression correlates with tumor necrosis extension in renal cell carcinoma

21 January 2018

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Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B.

21 January 2018

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An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

21 January 2018

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Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping

21 January 2018

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CXCL10 Can Inhibit Endothelial Cell Proliferation Independently of CXCR3

21 January 2018

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CXCR7 functions as a scavenger for CXCL12 and CXCL11

21 January 2018

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Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3 T cells in lymphocyte-rich gastric carcinoma

21 January 2018

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Synergistic antitumor effect of CXCL10 with hyperthermia

21 January 2018

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The angiostatic activity of interferon-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan

21 January 2018

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IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer

21 January 2018

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Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer

21 January 2018

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Chemokine expression in melanoma metastases associated with CD8 T-cell recruitment

21 January 2018

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CXCL10 expression and prognostic significance in stage II and III colorectal cancer

21 January 2018

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Overexpression of CXCL10 in human prostate LNCaP cells activates its receptor (CXCR3) expression and inhibits cell proliferation

21 January 2018

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Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model

21 January 2018

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Improved therapeutic effectiveness by combining recombinant CXC chemokine ligand 10 with Cisplatin in solid tumors

21 January 2018

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Combination of MIG (CXCL9) chemokine gene therapy with low-dose cisplatin improves therapeutic efficacy against murine carcinoma

21 January 2018

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The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8 T lymphocytes but not inhibition of angiogenesis

21 January 2018

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Colon carcinoma cells induce CXCL11-dependent migration of CXCR3-expressing cytotoxic T lymphocytes in organotypic culture.

21 January 2018

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CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells

21 January 2018

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CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model

21 January 2018

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The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines

21 January 2018

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Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer

21 January 2018

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Chemokine receptor CXCR3 promotes growth of glioma

21 January 2018

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Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.

21 January 2018

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CXCL10 promotes invasion-related properties in human colorectal carcinoma cells

21 January 2018

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The chemokine receptor CXCR3 is an independent prognostic factor in patients with localized clear cell renal cell carcinoma

21 January 2018

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CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: correlation with clinicopathological prognostic factors

21 January 2018

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The gene expression signatures of melanoma progression

21 January 2018

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Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes

21 January 2018

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CXCR3-binding chemokines in multiple myeloma

21 January 2018

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Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck

21 January 2018

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Roles for aberrant CXCR3 signaling in basal cell carcinoma: a case for dual activity

21 January 2018

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CXCR3/ligands are significantly involved in the tumorigenesis of basal cell carcinomas

21 January 2018

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Chemokine receptor antagonists: part 2.

21 January 2018

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CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors

21 January 2018

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Towards small-molecule CXCR3 ligands with clinical potential.

21 January 2018

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Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.

21 January 2018

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Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism

21 January 2018

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CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.

21 January 2018

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21 January 2018

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Chemokine signaling in cancer: one hump or two?

21 January 2018

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CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

21 January 2018

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Potential of CXCR4 antagonists for the treatment of metastatic lung cancer

21 January 2018

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The role of chemokine receptor CXCR4 in lung cancer

21 January 2018

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CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target

21 January 2018

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Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors

21 January 2018

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CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

21 January 2018

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Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain

21 January 2018

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Therapeutic targets for bone metastases in breast cancer

21 January 2018

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Future directions of bone-targeted therapy for metastatic breast cancer

21 January 2018

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The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?

21 January 2018

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CXCR4 regulates growth of both primary and metastatic breast cancer

21 January 2018

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Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

21 January 2018

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Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4.

21 January 2018

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Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside

21 January 2018

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Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth

21 January 2018

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A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer

21 January 2018

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Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer

21 January 2018

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Novel strategies for blood stem cell mobilization: special focus on plerixafor

21 January 2018

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Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist

21 January 2018

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Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1.

21 January 2018

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Agonists for the Chemokine Receptor CXCR4.

21 January 2018

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Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.

21 January 2018

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

21 January 2018

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A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer

21 January 2018

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Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients

21 January 2018

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Role of CXCL13-CXCR5 crosstalk between malignant neuroblastoma cells and Schwannian stromal cells in neuroblastic tumors.

21 January 2018

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CXCR5 may be involved in the attraction of human metastatic neuroblastoma cells to the bone marrow.

21 January 2018

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The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver

21 January 2018

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Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression.

21 January 2018

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CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation

21 January 2018

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Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy

21 January 2018

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A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells

21 January 2018

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Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines

21 January 2018

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Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion

21 January 2018

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CXCL13 and CXCL12 in central nervous system lymphoma patients.

21 January 2018

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CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation

21 January 2018

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PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

21 January 2018

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The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

21 January 2018

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ADAM17: a molecular switch to control inflammation and tissue regeneration

21 January 2018

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The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

21 January 2018

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Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients

21 January 2018

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Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response

21 January 2018

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High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer

21 January 2018

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CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro

21 January 2018

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Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation

21 January 2018

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Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.

21 January 2018

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CXCR6 and CCR5 localize T lymphocyte subsets in nasopharyngeal carcinoma

21 January 2018

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The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers

21 January 2018

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Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia

21 January 2018

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Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapy

21 January 2018

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Expression of the CXCR6 on polymorphonuclear neutrophils in pancreatic carcinoma and in acute, localized bacterial infections

21 January 2018

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CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway

21 January 2018

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CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells

21 January 2018

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Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma

21 January 2018

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CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells.

21 January 2018

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Biomarkers in renal cell carcinoma

21 January 2018

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Expression and regulation of the chemokine CXCL16 in Crohnʼs disease and models of intestinal inflammation

21 January 2018

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Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis

21 January 2018

1 reference

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.12.48

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1 August 2017

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