S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling (Q34250906)

31 July 2017

title

S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling (English)

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31 July 2017

Ikhlas S A Ahmed

1

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31 July 2017

Cora Chamberlain

series ordinal

2

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31 July 2017

Rolf J Craven

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

1 February 2012

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Expert Opinion on Drug Metabolism & Toxicology

31 July 2017

published in

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31 July 2017

volume

8

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31 July 2017

issue

3

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31 July 2017

page(s)

361-370

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PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding

31 July 2017

cites work

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Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo

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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

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Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.

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Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker

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Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors

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Gene expression profiles in human non-small and small-cell lung cancers

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Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1.

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Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.

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σ Binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture

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Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity

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Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

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Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.

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Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the sigma receptor family?

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Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

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Transcriptional activation of the membrane-bound progesterone receptor (mPR) by dioxin, in endocrine-responsive tissues

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Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity

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Purification and partial sequencing of high-affinity progesterone-binding site(s) from porcine liver membranes

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Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm

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17β-estradiol and progesterone regulate multiple progestin signaling molecules in the anteroventral periventricular nucleus, ventromedial nucleus and sexually dimorphic nucleus of the preoptic area in female rats

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Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation

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Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development

21 January 2018

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A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis

21 January 2018

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Molecular identification of adrenal inner zone antigen as a heme-binding protein

21 January 2018

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Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action

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Sigma receptors. Putative links between nervous, endocrine and immune systems

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Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems

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Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels

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Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines

21 January 2018

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Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor

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Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase

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Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

21 January 2018

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Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae

21 January 2018

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Cytochromes P450--a family of proteins and scientists-understanding their relationships

21 January 2018

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The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

21 January 2018

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Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain

21 January 2018

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Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p

21 January 2018

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Measurement of the heme affinity for yeast dap1p, and its importance in cellular function

21 January 2018

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Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

21 January 2018

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Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis

21 January 2018

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Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs

21 January 2018

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A helping hand for cytochrome p450 enzymes.

21 January 2018

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Progesterone Receptor Membrane Component 1 Inhibits the Activity of Drug-Metabolizing Cytochromes P450 and Binds to Cytochrome P450 Reductase

21 January 2018

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Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure

21 January 2018

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Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor

21 January 2018

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Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells

21 January 2018

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Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.

21 January 2018

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https://api.crossref.org/works/10.1517/17425255.2012.658367

Aromatase excess in cancers of breast, endometrium and ovary

21 January 2018

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https://api.crossref.org/works/10.1517/17425255.2012.658367

Aromatase inhibitors in human lung cancer therapy.

21 January 2018

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https://api.crossref.org/works/10.1517/17425255.2012.658367

Pharmacokinetics of haloperidol: an update

21 January 2018

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https://api.crossref.org/works/10.1517/17425255.2012.658367

Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17425255.2012.658367

The effects of antipsychotic therapy on serum lipids: a comprehensive review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17425255.2012.658367

Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17425255.2012.658367

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17425255.2012.658367

Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17425255.2012.658367

10.1517/17425255.2012.658367

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference