A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells (Q34249643)

31 July 2017

title

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells (English)

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31 July 2017

O Villamar-Cruz

2

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Jonathan Chernoff

object named as

J Chernoff

7

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author name string

L E Arias-Romero

1

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31 July 2017

A Pacheco

3

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31 July 2017

R Kosoff

4

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31 July 2017

M Huang

5

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31 July 2017

S K Muthuswamy

6

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31 July 2017

language of work or name

English

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publication date

16 August 2010

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31 July 2017

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31 July 2017

volume

29

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31 July 2017

issue

43

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31 July 2017

page(s)

5839-5849

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describes a project that uses

31 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2965784/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

ErbB receptors and signaling pathways in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Pak protein kinases and their role in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Scaffolding function of PAK in the PDK1-Akt pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Construction of adenovirus vectors through Cre-lox recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965784

6 July 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Biology of the p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

p21-activated kinases: three more join the Pak.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

The activation of an extracellular signal-regulated kinase by oestradiol interferes with the effects of trastuzumab on HER2 signalling in endometrial adenocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

PAK1 hyperactivation is sufficient for mammary gland tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.318

21 January 2018

Identifiers

DOI

10.1038/ONC.2010.318

1 reference

Dimensions Publication ID

31 July 2017

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1 reference

31 July 2017

1 reference