Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect. (Q34249210)

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12 March 2020

title

Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect (English)

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5

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14

Fadlo R Khuri

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Titus J Boggon

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author name string

Jun Fan

1

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Hee-Bum Kang

2

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Changliang Shan

3

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Shannon Elf

4

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Jianxin Xie

6

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Ting-Lei Gu

7

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Mike Aguiar

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Scott Lonning

9

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Tae-Wook Chung

10

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Martha Arellano

11

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Hanna J Khoury

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Dong M Shin

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Sumin Kang

16

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Jing Chen

17

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language of work or name

English

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publication date

7 August 2014

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Journal of Biological Chemistry

12 March 2020

published in

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volume

289

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issue

38

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page(s)

26533-26541

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Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

12 March 2020

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Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

6 July 2018

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Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

6 July 2018

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Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD( ) redox homeostasis in cancer cells

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

6 July 2018

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Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex

6 July 2018

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Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

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Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components

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Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Crossref

https://api.crossref.org/works/10.1074/JBC.M114.593970

Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25104357

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.593970

1 reference

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12 March 2020

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12 March 2020

PubMed publication ID

25104357

1 reference