Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer (Q34249190)

31 July 2017

title

Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. (English)

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31 July 2017

1 reference

Kush Dalal

1

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31 July 2017

Mani Roshan-Moniri

2

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31 July 2017

Aishwariya Sharma

3

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31 July 2017

Huifang Li

4

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31 July 2017

Fuqiang Ban

5

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31 July 2017

Mohamed D Hassona

6

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31 July 2017

Michael Hsing

7

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31 July 2017

Kriti Singh

8

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31 July 2017

Eric LeBlanc

9

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31 July 2017

Scott Dehm

10

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31 July 2017

Emma S Tomlinson Guns

11

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31 July 2017

Artem Cherkasov

12

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31 July 2017

Paul S Rennie

13

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31 July 2017

language of work or name

English

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publication date

1 August 2014

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Journal of Biological Chemistry

31 July 2017

published in

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31 July 2017

volume

289

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31 July 2017

issue

38

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31 July 2017

page(s)

26417-26429

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Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor

31 July 2017

cites work

1 reference

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TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.

6 July 2018

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6 July 2018

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6 July 2018

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A novel antiandrogen, Compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

6 July 2018

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6 July 2018

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Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

6 July 2018

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Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets

6 July 2018

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6 July 2018

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

6 July 2018

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Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

6 July 2018

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Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor

6 July 2018

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6 July 2018

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6 July 2018

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Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells

6 July 2018

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Development of a second-generation antiandrogen for treatment of advanced prostate cancer

6 July 2018

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A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

6 July 2018

1 reference

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In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors.

6 July 2018

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Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

6 July 2018

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

6 July 2018

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Structural basis for the nuclear import of the human androgen receptor

6 July 2018

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Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts

6 July 2018

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A surface on the androgen receptor that allosterically regulates coactivator binding

6 July 2018

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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

6 July 2018

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Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression

6 July 2018

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Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

6 July 2018

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Structural basis for antagonism and resistance of bicalutamide in prostate cancer

6 July 2018

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Chemogenomics: an emerging strategy for rapid target and drug discovery

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Structural basis of androgen receptor binding to selective androgen response elements.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

The program of androgen-responsive genes in neoplastic prostate epithelium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Differential transactivation by the androgen receptor in prostate cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4176249

Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074/JBC.M114.553818

Stepwise androgen receptor dimerization

21 January 2018

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12 December 2020

Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models

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12 December 2020

Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model

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12 December 2020

Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.553818

1 reference

31 July 2017

1 reference

31 July 2017

1 reference