Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (Q34245963)

31 July 2017

title

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (English)

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31 July 2017

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Bruno Sainz

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ORCID Public Data File 2021

Kazuaki Chayama

9

object named as

Kazuaki Chayama

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31 July 2017

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Michio Imamura

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31 July 2017

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Nobuhiko Hiraga

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31 July 2017

Naina Barretto

2

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31 July 2017

Danyelle N Martin

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31 July 2017

Snawar Hussain

6

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31 July 2017

Katherine A Marsh

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31 July 2017

Xuemei Yu

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31 July 2017

Waddah A Alrefai

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31 July 2017

Susan L Uprichard

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31 July 2017

language of work or name

English

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publication date

8 January 2012

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31 July 2017

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31 July 2017

volume

18

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31 July 2017

issue

2

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31 July 2017

page(s)

281-285

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The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.

31 July 2017

cites work

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Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus

6 July 2018

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EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

6 July 2018

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Hepatitis C virus experimental model systems and antiviral drug research

6 July 2018

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Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids

6 July 2018

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Cell-based hepatitis C virus infection fluorescence resonance energy transfer (FRET) assay for antiviral compound screening

6 July 2018

1 reference

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The rate of hepatitis C virus infection initiation in vitro is directly related to particle density.

6 July 2018

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RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis

6 July 2018

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Transporters as drug targets: discovery and development of NPC1L1 inhibitors

6 July 2018

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Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

6 July 2018

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Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

6 July 2018

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Primary hepatocytes as targets for hepatitis C virus replication

6 July 2018

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Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

6 July 2018

1 reference

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Extracellular loop C of NPC1L1 is important for binding to ezetimibe

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Ezetimibe blocks internalization of the NPC1L1/cholesterol complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

The structure and function of Niemann-Pick C1-like 1 protein

6 July 2018

1 reference

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Ezetimibe: cholesterol lowering and beyond

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion

6 July 2018

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Ezetimibe: an update on the mechanism of action, pharmacokinetics and recent clinical trials

6 July 2018

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Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

6 July 2018

1 reference

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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus and Host

6 July 2018

1 reference

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Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Near completely humanized liver in mice shows human-type metabolic responses to drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Ezetimibe: the first in a novel class of selective cholesterol-absorption inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Binding of hepatitis C virus to CD81

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530957

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

6 July 2018

1 reference

In vivo study of HCV in mice with chimeric human livers

21 January 2018

1 reference

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

21 January 2018

1 reference

Localization and role of NPC1L1 in cholesterol absorption in human intestine

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NM.2581

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Dimensions Publication ID

31 July 2017

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31 July 2017

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