Eukaryotic initiation factor 4F: a vulnerability of tumor cells (Q34240544)

31 July 2017

title

Eukaryotic initiation factor 4F: a vulnerability of tumor cells (English)

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31 July 2017

Teresa Lee

1

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31 July 2017

Jerry Pelletier

series ordinal

2

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31 July 2017

publication date

1 January 2012

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Future Medicinal Chemistry

31 July 2017

published in

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31 July 2017

volume

4

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31 July 2017

issue

1

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31 July 2017

page(s)

19-31

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Reversibility of oncogene-induced cancer

31 July 2017

cites work

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21 January 2018

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Non-oncogene addiction and the stress phenotype of cancer cells

21 January 2018

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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

21 January 2018

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Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

21 January 2018

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A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA

21 January 2018

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Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking

21 January 2018

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The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro

21 January 2018

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Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit

21 January 2018

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Molecular mechanisms of translation initiation in eukaryotes

21 January 2018

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Functional analysis of individual binding activities of the scaffold protein eIF4G

21 January 2018

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Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A

21 January 2018

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Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.

21 January 2018

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Structural basis for the enhancement of eIF4A helicase activity by eIF4G.

21 January 2018

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A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

21 January 2018

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

21 January 2018

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Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

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The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

21 January 2018

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

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Dendritic location of neural BC1 RNA

21 January 2018

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Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism

21 January 2018

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Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

21 January 2018

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Extracellular signals and reversible protein phosphorylation: what to Mek of it all.

21 January 2018

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Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

21 January 2018

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Dissecting eIF4E action in tumorigenesis

21 January 2018

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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

21 January 2018

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Sumoylation of eIF4E activates mRNA translation

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

21 January 2018

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An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

21 January 2018

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c-Myc and eIF4F are components of a feedforward loop that links transcription and translation

21 January 2018

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MYC as a regulator of ribosome biogenesis and protein synthesis

21 January 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

21 January 2018

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Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).

21 January 2018

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Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells

21 January 2018

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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

21 January 2018

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

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Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

21 January 2018

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Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis

21 January 2018

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Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

21 January 2018

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Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.

21 January 2018

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Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome

21 January 2018

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Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

21 January 2018

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Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer

21 January 2018

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eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

21 January 2018

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Phosphorylated 4E-BP1 is associated with poor survival in melanoma

21 January 2018

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4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

21 January 2018

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Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

21 January 2018

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The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

21 January 2018

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Control of mammalian translation by mRNA structure near caps

21 January 2018

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

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Translational control: the cancer connection

21 January 2018

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Translation initiation and its deregulation during tumorigenesis

21 January 2018

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

21 January 2018

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Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

21 January 2018

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Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.

21 January 2018

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Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.

21 January 2018

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Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.

21 January 2018

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Stabilizing the eIF4G1 α-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies.

21 January 2018

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Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.

21 January 2018

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Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.

21 January 2018

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Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation.

21 January 2018

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Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.

21 January 2018

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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

21 January 2018

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

21 January 2018

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Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

21 January 2018

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Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

21 January 2018

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Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.

21 January 2018

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Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides

21 January 2018

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Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

21 January 2018

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A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus

21 January 2018

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Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

21 January 2018

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Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

21 January 2018

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Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.

21 January 2018

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The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

21 January 2018

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Mechanisms of action of ribavirin in antiviral therapies

21 January 2018

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Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

21 January 2018

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

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The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation

21 January 2018

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Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.

21 January 2018

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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

21 January 2018

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Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

21 January 2018

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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

21 January 2018

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Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen

21 January 2018

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Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

21 January 2018

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Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.

21 January 2018

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Selective pharmacological targeting of a DEAD box RNA helicase.

21 January 2018

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Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia

21 January 2018

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Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities

21 January 2018

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Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.

21 January 2018

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Efficient Synthetic Approach to Potent Antiproliferative Agent Hippuristanol via Hg(II)-Catalyzed Spiroketalization

21 January 2018

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Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

21 January 2018

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Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.

21 January 2018

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Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation

21 January 2018

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Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII

21 January 2018

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Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.

21 January 2018

1 reference

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

21 January 2018

1 reference

Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae).

21 January 2018

1 reference

Insecticidal flavaglines and other compounds from Fijian Aglaia species

21 January 2018

1 reference

Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica.

21 January 2018

1 reference

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris

21 January 2018

1 reference

Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata

21 January 2018

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Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells

21 January 2018

1 reference

Constituents of the Leaves and Stem Bark of Aglaia foveolata

21 January 2018

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Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry

21 January 2018

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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

21 January 2018

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The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

21 January 2018

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Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

21 January 2018

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Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

21 January 2018

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Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

21 January 2018

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Enantioselective synthesis of the complex rocaglate (-)-silvestrol

21 January 2018

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Biomimetic Photocycloaddition of 3‐Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

21 January 2018

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Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells

21 January 2018

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Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes

21 January 2018

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Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery

21 January 2018

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The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection

21 January 2018

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Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent

21 January 2018

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Translation driven by an eIF4G core domain in vivo

21 January 2018

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

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Total Synthesis of (−)-Episilvestrol and (−)-Silvestrol

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.11.150

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release_kqdvabqatfervlrprfj3zc23iq

31 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kqdvabqatfervlrprfj3zc23iq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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