Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. (Q34232143)

31 July 2017

title

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. (English)

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amyotrophic lateral sclerosis

31 July 2017

main subject

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author name string

Sang Hwa Kim

1

1 reference

31 July 2017

Naval P Shanware

2

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31 July 2017

Michael J Bowler

3

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31 July 2017

Randal S Tibbetts

4

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31 July 2017

language of work or name

English

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publication date

18 August 2010

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Journal of Biological Chemistry

31 July 2017

published in

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31 July 2017

volume

285

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31 July 2017

issue

44

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31 July 2017

page(s)

34097-34105

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

31 July 2017

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Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

6 July 2018

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

6 July 2018

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

6 July 2018

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6 July 2018

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Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

6 July 2018

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Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

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Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

6 July 2018

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Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

6 July 2018

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6 July 2018

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6 July 2018

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Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

6 July 2018

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6 July 2018

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

6 July 2018

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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

6 July 2018

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

6 July 2018

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

6 July 2018

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

6 July 2018

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Structural insights into TDP-43 in nucleic-acid binding and domain interactions

6 July 2018

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

6 July 2018

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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

6 July 2018

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Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.

6 July 2018

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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 July 2018

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A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

6 July 2018

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

6 July 2018

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6 July 2018

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Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

6 July 2018

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HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

6 July 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

6 July 2018

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TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein

6 July 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 July 2018

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TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

6 July 2018

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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

6 July 2018

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TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962508

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

6 July 2018

1 reference

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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

6 July 2018

1 reference

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TDP-43 mutation in familial amyotrophic lateral sclerosis

6 July 2018

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https://api.crossref.org/works/10.1074/JBC.M110.154831

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.154831

The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.154831

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.154831

21 January 2018

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28 October 2018

Identifiers

DOI

10.1074/JBC.M110.154831

1 reference

31 July 2017

1 reference

31 July 2017

1 reference