The promise and potential hazards of adenovirus gene therapy (Q34219407)

31 July 2017

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title

The promise and potential hazards of adenovirus gene therapy (English)

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31 July 2017

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Young LS

1

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31 July 2017

Mautner V

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 May 2001

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31 July 2017

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31 July 2017

volume

48

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31 July 2017

issue

5

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31 July 2017

page(s)

733-736

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Obstacles and advances in non-viral gene delivery

31 July 2017

cites work

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5 July 2018

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

5 July 2018

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5 July 2018

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Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

5 July 2018

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5 July 2018

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5 July 2018

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Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR

5 July 2018

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Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

5 July 2018

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An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

5 July 2018

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Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration

5 July 2018

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5 July 2018

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An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

5 July 2018

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Targeted gene delivery by tropism-modified adenoviral vectors

5 July 2018

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Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

5 July 2018

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In Vitro and In Vivo Biology of Recombinant Adenovirus Vectors with E1, E1/E2A, or E1/E4 Deleted

5 July 2018

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Production and Characterization of Improved Adenovirus Vectors with the E1, E2b, and E3 Genes Deleted

5 July 2018

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Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products

5 July 2018

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Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.

5 July 2018

1 reference

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Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver

5 July 2018

1 reference

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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

5 July 2018

1 reference

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A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging.

5 July 2018

1 reference

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Persistence in muscle of an adenoviral vector that lacks all viral genes

5 July 2018

1 reference

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Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

5 July 2018

1 reference

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Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.

5 July 2018

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A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

5 July 2018

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Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2.

5 July 2018

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Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism.

5 July 2018

1 reference

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Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro.

5 July 2018

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Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues

5 July 2018

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A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase

5 July 2018

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Addition of a short peptide ligand to the adenovirus fiber protein.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Association of human class I MHC alleles with the adenovirus E3/19K protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Regulation of TNF-mediated cell death and inflammation by human adenoviruses.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Identification of Adenovirus E1A Regions Which Affect MHC Class I Expression and Susceptibility to Cytotoxic T Lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Role of early region 3 (E3) in pathogenesis of adenovirus disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Infection of Mouse Liver by Human Adenovirus Type 5

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

5 July 2018

Gene therapy on trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Receptors mediating adenovirus attachment and internalization

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1728283

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

28 October 2018

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12 December 2020

Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice

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12 December 2020

Characterization of human proliferative T cell responses to adenovirus

1 reference

12 December 2020

"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype

1 reference

12 December 2020

Identifiers

DOI

10.1136/GUT.48.5.733

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31 July 2017

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31 July 2017

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