The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis (Q34206346)

31 July 2017

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title

The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis (English)

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31 July 2017

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Smela ME

1

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31 July 2017

Currier SS

series ordinal

2

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31 July 2017

Bailey EA

series ordinal

3

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31 July 2017

Essigmann JM

series ordinal

4

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31 July 2017

language of work or name

English

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publication date

1 April 2001

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31 July 2017

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31 July 2017

volume

22

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31 July 2017

issue

4

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31 July 2017

page(s)

535-545

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Mutational hot spot in the p53 gene in human hepatocellular carcinomas

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

In vitro reactions of aflatoxin B1-adducted DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutational properties of the primary aflatoxin B1-DNA adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Base substitution mutations induced by metabolically activated aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutagenesis by apurinic/apyrimidinic sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutagenic properties of a unique abasic site in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Apurinic sites cause mutations in simian virus 40

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutagenesis by apurinic sites in normal and ataxia telangiectasia human lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Sequence specificity in aflatoxin B1--DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

An intercalation inhibitor altering the target selectivity of DNA damaging agents: Synthesis of site-specific aflatoxin B 1 adducts in a p53 mutational hotspot

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Sequence context effects in DNA replication blocks induced by aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Preferential binding of aflatoxin B1 to the transcriptionally active regions of rat liver nucleolar chromatin in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Effect of 5-methylcytosine as a neighboring base on methylation of DNA guanine by N-methyl-N-nitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

5-Methylcytosine in CpG sites and the reactivity of nearest neighboring guanines toward the carcinogen aflatoxin B1-8,9-epoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Genetic alterations during colorectal-tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

In vitro activation of the human Harvey-ras proto-oncogene by aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Hepatitis B virus X protein inhibits nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450- expressing human liver cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain. A study of 129 archival tumour samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Reconstitution of human base excision repair with purified proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

p53-dependent cell cycle control: response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

A comparison of induced mutation at homologous alleles of the tk locus in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

The dual role model for p53 in maintaining genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mechanisms of p53-induced apoptosis: in search of genes which are regulated during p53-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Introduction: p53--the first twenty years

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Interaction of p53 with the Human Rad51 Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Transcriptional repression of the human p53 gene by hepatitis B viral X protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Absence of p53 mutation at codon 249 in duck hepatocellular carcinomas from the high incidence area of Qidong (China).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Transfection of a rat hepatoma cell line with a construct expressing human liver annexin V confers susceptibility to hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin B1 to DNA in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mouse strain differences in glutathione S-transferase activity and aflatoxin B1 biotransformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Comparison of the aflatoxin B1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in woodchucks infected with woodchuck hepatitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Human hepatitis B virus and hepatocellular carcinoma. II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Kinds of mutations induced by aflatoxin B1 in a shuttle vector replicating in human cells transiently expressing cytochrome P450IA2 cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Aflatoxin B -oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes guanine substitution in nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

Prevalence of ras gene mutations in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/22.4.535

21 January 2018

Identifiers

DOI

10.1093/CARCIN/22.4.535

1 reference

31 July 2017

1 reference