ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis (Q34205901)

31 July 2017

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title

ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis (English)

1 reference

31 July 2017

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis (English)

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8 December 2024

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Priyanka Verma

1

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31 July 2017

Krishna Dalal

2

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31 July 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21815191

8 December 2024

publication date

1 December 2011

1 reference

31 July 2017

December 2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21815191

full work available at URL

8 December 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002/jcb.23298

1 reference

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcb.23298/fullpdf

8 December 2024

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Journal of Cellular Biochemistry

8 December 2024

published in

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31 July 2017

volume

112

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31 July 2017

issue

12

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31 July 2017

page(s)

3507-3514

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

31 July 2017

cites work

1 reference

A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms

21 January 2018

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The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

21 January 2018

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Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions

21 January 2018

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Metalloproteinases: their role in arthritis and potential as therapeutic targets

21 January 2018

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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

21 January 2018

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Risk factors for the incidence and progression of radiographic knee osteoarthritis

21 January 2018

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Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

21 January 2018

1 reference

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

21 January 2018

1 reference

The futility of current approaches to chondroprotection

21 January 2018

1 reference

Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

21 January 2018

1 reference

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

21 January 2018

1 reference

Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation

21 January 2018

1 reference

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

21 January 2018

1 reference

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

21 January 2018

1 reference

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 January 2018

1 reference

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration

21 January 2018

1 reference

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors

21 January 2018

1 reference

Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions

21 January 2018

1 reference

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

21 January 2018

1 reference

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

21 January 2018

1 reference

Expression profiling of metalloproteinases and their inhibitors in cartilage

21 January 2018

1 reference

The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction

21 January 2018

1 reference

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

21 January 2018

1 reference

The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential

21 January 2018

1 reference

ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein

21 January 2018

1 reference

Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.

21 January 2018

1 reference

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

21 January 2018

1 reference

Metalloproteases and inhibitors in arthritic diseases

21 January 2018

1 reference

Osteoarthritis of the knee joint: an eight year prospective study

21 January 2018

1 reference

Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member

21 January 2018

1 reference

Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.

21 January 2018

1 reference

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

21 January 2018

1 reference

Aggrecanases and cartilage matrix degradation

21 January 2018

1 reference

The ADAMTS metalloproteinases

21 January 2018

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Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

21 January 2018

1 reference

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

21 January 2018

1 reference

Variations in aggrecan structure modulate its susceptibility to aggrecanases

21 January 2018

1 reference

Leech thrombin inhibitors

21 January 2018

1 reference

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

21 January 2018

1 reference

Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors

21 January 2018

1 reference

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

21 January 2018

1 reference

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

21 January 2018

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Radiological progression of osteoarthritis: an 11 year follow up study of the knee

21 January 2018

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

21 January 2018

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

21 January 2018

1 reference

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

21 January 2018

1 reference

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

21 January 2018

1 reference

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

21 January 2018

1 reference

Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function.

21 January 2018

1 reference

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

21 January 2018

1 reference

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

21 January 2018

1 reference

Potent P1' biphenylmethyl substituted aggrecanase inhibitors

21 January 2018

1 reference

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

21 January 2018

1 reference

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

21 January 2018

1 reference

A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family

21 January 2018

2

1 reference

Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate

8 December 2024

5

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ADAMTS-5: the story so far.

8 December 2024

15

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5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

8 December 2024

19

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N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

8 December 2024

20

1 reference

Effect of repeated infliximab therapy on serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with rheumatoid arthritis

8 December 2024

29

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ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

8 December 2024

33

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The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

8 December 2024

35

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Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors

8 December 2024

45

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8 December 2024

48

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Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein

8 December 2024

49

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Identification of aggrecanase activity in medium of cartilage culture

8 December 2024

60

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The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

8 December 2024

62

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8 December 2024

Identifiers

DOI

10.1002/JCB.23298

1 reference

31 July 2017

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