Cbl: many adaptations to regulate protein tyrosine kinases (Q34205572)

31 July 2017

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title

Cbl: many adaptations to regulate protein tyrosine kinases (English)

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31 July 2017

C B Thien

1

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31 July 2017

W Y Langdon

series ordinal

2

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31 July 2017

publication date

1 April 2001

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

4

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31 July 2017

page(s)

294-307

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v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

31 July 2017

cites work

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cbl-3: a new mammalian cbl family protein

21 January 2018

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Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.

21 January 2018

1 reference

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.

21 January 2018

1 reference

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo

21 January 2018

1 reference

21 January 2018

1 reference

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

21 January 2018

1 reference

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

21 January 2018

1 reference

Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

21 January 2018

1 reference

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene

21 January 2018

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Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

21 January 2018

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

Evidence for direct interaction between Sprouty and Cbl

21 January 2018

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sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

21 January 2018

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Sprouty, an intracellular inhibitor of Ras signaling.

21 January 2018

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Activation-modulated association of 14-3-3 proteins with Cbl in T cells

21 January 2018

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Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif

21 January 2018

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Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

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Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

21 January 2018

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Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

21 January 2018

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Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

21 January 2018

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The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

21 January 2018

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Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

21 January 2018

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Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism

21 January 2018

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Ras-dependent, Ca2 -stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.

21 January 2018

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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

21 January 2018

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The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

21 January 2018

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

21 January 2018

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

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Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor

21 January 2018

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D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis

21 January 2018

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cbl-b inhibits epidermal growth factor receptor signaling

21 January 2018

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 January 2018

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Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

21 January 2018

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c-Cbl is a suppressor of the neu oncogene

21 January 2018

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RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

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Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling

21 January 2018

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Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation

21 January 2018

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Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

21 January 2018

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The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases

21 January 2018

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The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells

21 January 2018

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Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

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A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

21 January 2018

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Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway

21 January 2018

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Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.

21 January 2018

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A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells

21 January 2018

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Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association

21 January 2018

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

21 January 2018

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Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

21 January 2018

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Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

21 January 2018

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Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.

21 January 2018

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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

21 January 2018

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The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.

21 January 2018

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Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells

21 January 2018

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

21 January 2018

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The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

21 January 2018

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Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

21 January 2018

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Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein

21 January 2018

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The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction

21 January 2018

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The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

21 January 2018

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A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

21 January 2018

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Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl

21 January 2018

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Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation

21 January 2018

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A function for monoubiquitination in the internalization of a G protein-coupled receptor

21 January 2018

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Recognition of the polyubiquitin proteolytic signal

21 January 2018

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The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

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The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

21 January 2018

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A Di-leucine Signal in the Ubiquitin Moiety

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

21 January 2018

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7 January 2021

Role of protein kinase C in signal attenuation following T cell receptor engagement

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7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1 reference

7 January 2021

The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor

1 reference

7 January 2021

Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways

1 reference

7 January 2021

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

7 January 2021

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

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7 January 2021

Primate evolution--in and out of Africa

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7 January 2021

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells

1 reference

7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

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7 January 2021

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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7 January 2021

Identifiers

DOI

10.1038/35067100

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Dimensions Publication ID

31 July 2017

1029980557

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