Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles (Q34201670)

31 July 2017

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title

Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles (English)

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31 July 2017

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S Janciauskiene

1

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31 July 2017

language of work or name

English

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publication date

1 March 2001

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Biochimica et Biophysica Acta

31 July 2017

published in

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31 July 2017

volume

1535

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31 July 2017

issue

3

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31 July 2017

page(s)

221-235

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Molecular evolution of serpins: homologous structure of the human alpha 1-antichymotrypsin and alpha 1-antitrypsin genes

31 July 2017

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The serpins: evolution and adaptation in a family of protease inhibitors

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Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins

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Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors

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Ovalbumin and angiotensinogen lack serpin S-R conformational change

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Serpins and regulation of cell death

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The expanding superfamily of serpins: searching for the real targets

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Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells

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Maspin is an angiogenesis inhibitor

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Molecular Cloning of Bomapin (Protease Inhibitor 10), a Novel Human Serpin That Is Expressed Specifically in the Bone Marrow

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Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins

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SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation

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7 January 2021

Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1

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Human plasma proteinase inhibitors

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What do dysfunctional serpins tell us about molecular mobility and disease?

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

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7 January 2021

Structure of a serpin-protease complex shows inhibition by deformation

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7 January 2021

Conformational stability of the covalent complex between elastase and alpha 1-proteinase inhibitor

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7 January 2021

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

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7 January 2021

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

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7 January 2021

Structural basis for serpin inhibitor activity

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7 January 2021

The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase

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7 January 2021

Antithrombin and its deficiency states

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7 January 2021

Alpha-1-antitrypsin deficiency: biochemistry and clinical manifestations

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7 January 2021

Biochemical characterization of a neuroserpin variant associated with hereditary dementia

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7 January 2021

Heparin promotes the inactivation of antithrombin by neutrophil elastase

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7 January 2021

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

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7 January 2021

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

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7 January 2021

Novel functions of human alpha(1)-protease inhibitor after S-nitrosylation: inhibition of cysteine protease and antibacterial activity

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7 January 2021

alpha(1)-antitrypsin can increase insulin-induced mitogenesis in various fibroblast and epithelial cell lines

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7 January 2021

Serpins identified as cell growth inhibitors in human plasma.

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7 January 2021

Oxidative inactivation of purified human alpha-2-antiplasmin, antithrombin III, and C1-inhibitor

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7 January 2021

Serpins: implications of a mobile reactive centre

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7 January 2021

Antiangiogenic activity of the cleaved conformation of the serpin antithrombin

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7 January 2021

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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7 January 2021

Angiostatin generation by human tumor cell lines: involvement of plasminogen activators.

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7 January 2021

Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas

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7 January 2021

Morphological identification of alpha-I-antitrypsin in the human small intestine

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7 January 2021

Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor

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7 January 2021

Local control of alpha1-proteinase inhibitor levels: regulation of alpha1-proteinase inhibitor in the human cornea by growth factors and cytokines

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7 January 2021

Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes

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7 January 2021

Structure, function, and control of neutrophil proteinases

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7 January 2021

Alpha 1-antitrypsin deficiency. A conformational disease

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7 January 2021

Structure and variation of human alpha 1-antitrypsin

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7 January 2021

Discovery of alpha 1-antitrypsin deficiency

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7 January 2021

Liver Disease in Alpha1-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

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7 January 2021

Carcinogenesis of primary liver malignancies

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7 January 2021

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

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7 January 2021

Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages

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7 January 2021

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

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7 January 2021

Familial encephalopathy with neuroserpin inclusion bodies

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7 January 2021

Dysfibrinogenemia and thrombosis

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7 January 2021

A point mutation in exon 7 of the C1-inhibitor gene causing type I hereditary angioedema

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7 January 2021

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

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7 January 2021

Conformational changes in serpins: I. the native and cleaved conformations of α 1 -antitrypsin 1 1Edited by J. M. Thornton

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7 January 2021

In vitro fibril formation from alpha 1-antitrypsin-derived C-terminal peptides

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7 January 2021

Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Characterization of the receptor for protease nexin-I:protease complexes on human fibroblasts

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7 January 2021

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes

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7 January 2021

Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Binding of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex to the endocytosis receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of alpha-1 antitrypsin-elastase complexes and amyloid-beta peptide

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Complexes in plasma between light chain kappa immunoglobulins and alpha 1-antitrypsin respectively prealbumin.

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Evaluation of factor XIa-alpha 1-antitrypsin in plasma, a contact phase-activated coagulation factor-inhibitor complex, in patients with coronary artery disease

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7 January 2021

Comparison of IgA-alpha1-antitrypsin levels in rheumatoid arthritis and seronegative oligoarthritis: complex formation is not associated with inflammation per se.

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7 January 2021

Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases

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7 January 2021

The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.

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7 January 2021

Tissue destruction by neutrophils

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7 January 2021

Immunopathologic mechanisms in pemphigus and bullous pemphigoid

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7 January 2021

Cleaved antitrypsin polymers at atomic resolution

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7 January 2021

A 2.6 A structure of a serpin polymer and implications for conformational disease

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7 January 2021

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

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7 January 2021

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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7 January 2021

Isolation and characterization of hydrophobic polypeptides in human bile

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7 January 2021

Identification of hydrophobic fragments of alpha 1-antitrypsin and C1 protease inhibitor in human bile, plasma and spleen

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7 January 2021

Isolation and serine protease inhibitory activity of the 44-residue, C-terminal fragment of alpha 1-antitrypsin from human placenta

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7 January 2021

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus

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7 January 2021

Binding of SPAAT, the 44-residue C-terminal peptide of α1-antitrypsin, to proteins of the extracellular matrix

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7 January 2021

Bypassing the kinetic trap of serpin protein folding by loop extension

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7 January 2021

Atherogenic properties of human monocytes induced by the carboxyl terminal proteolytic fragment of alpha-1-antitrypsin

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7 January 2021

The carboxyl-terminal fragment of alpha1-antitrypsin is present in atherosclerotic plaques and regulates inflammatory transcription factors in primary human monocytes

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7 January 2021

Serum glycoproteins and severity of coronary atherosclerosis

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7 January 2021

Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha 1-antitrypsin and alpha 2-macroglobulin

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7 January 2021

Regulation of antitrypsin and antichymotrypsin synthesis by MCF-7 breast cancer cell sublines

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7 January 2021

Prognostic significance of alpha-1-antitrypsin in early stage of colorectal carcinomas

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7 January 2021

Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: a possible modulatory role in natural killer cytotoxicity

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7 January 2021

Oxidation of methionine residues in antithrombin. Effects on biological activity and heparin binding

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7 January 2021

Activation of the fifth component of human complement, C5, without cleavage, by methionine oxidizing agents

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7 January 2021

Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluid

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7 January 2021

Oxidation of methionyl residues in proteins: tools, targets, and reversal

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7 January 2021

Inactivation of alpha-1-proteinase inhibitor in serum by stimulated human polymorphonuclear leucocytes. Evidence for a myeloperoxidase-dependent mechanism

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7 January 2021

Inactivation of synovial fluid α1 -antitrypsin by exercise of the inflamed rheumatoid joint

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7 January 2021

Proteolysis of human native and oxidised α1-proteinase inhibitor by matrulysin and stromelysin

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7 January 2021

Inactivation of the elastase inhibitory activity of alpha 1 antitrypsin in fresh samples of synovial fluid from patients with rheumatoid arthritis

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7 January 2021

Oxidation of alpha1-proteinase inhibitor by the myeloperoxidase-hydrogen peroxidase system promotes binding to immunoglobulin A.

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7 January 2021

The proteinase-antiproteinase theory of emphysema: time for a reappraisal?

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7 January 2021

Smoking and chronic obstructive pulmonary disease

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7 January 2021

The effect of catalase and methionine-S-oxide reductase on oxidised alpha 1-proteinase inhibitor

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7 January 2021

The assessment of alpha 1 proteinase inhibitor form and function in lung lavage fluid from healthy subjects

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7 January 2021

Effect of cigarette smoking on pulmonary function in each phenotype M of alpha-1-protease inhibitor

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7 January 2021

Activation of primary human monocytes by the oxidized form of alpha1-antitrypsin

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7 January 2021

Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system

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7 January 2021

Serine protease inhibitors: novel therapeutic targets for stroke?

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7 January 2021

Serine proteases and brain damage - is there a link?

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7 January 2021

Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.

1 reference

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7 January 2021

Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Protease nexin-1 and thrombin modulate neuronal Ca2 homeostasis and sensitivity to glucose deprivation-induced injury

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning.

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy

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7 January 2021

The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease

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7 January 2021

Studies on the Proteolytic Degradation of theβ-Protein Precursor by Proteases Purified from Alzheimer's Disease Braina

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7 January 2021

Proteolytic Enzymes, their Inhibitors and Lung Diseases

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Synthesis of alpha 1-antichymotrypsin and alpha 1-antitrypsin by human trophoblast

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https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Prostate-specific antigen

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(01)50025-4

7 January 2021

Distribution pattern and functional state of alpha 1-antichymotrypsin in plaques and vascular amyloid in Alzheimer's disease. A immunohistochemical study with monoclonal antibodies against native and inactivated alpha 1-antichymotrypsin

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7 January 2021

Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A

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7 January 2021

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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7 January 2021

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

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7 January 2021

Review: modulating factors in amyloid-beta fibril formation

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7 January 2021

Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation

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7 January 2021

Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease

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7 January 2021

10.1016/S0925-4439(01)00025-4

Identifiers

DOI

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31 July 2017

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