Telomerase inhibition as cancer therapy. (Q34198649)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12757979 AND SRC:MED&resulttype=core&format=json

3 November 2019

review article

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title

Telomerase inhibition as cancer therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12757979 AND SRC:MED&resulttype=core&format=json

3 November 2019

1

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3 November 2019

author name string

Gabriele Saretzki

series ordinal

1

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31 July 2017

language of work or name

English

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publication date

1 May 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12757979 AND SRC:MED&resulttype=core&format=json

3 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12757979 AND SRC:MED&resulttype=core&format=json

3 November 2019

volume

194

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3 November 2019

issue

2

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3 November 2019

page(s)

209-219

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A survey of telomerase activity in human cancer

3 November 2019

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2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells

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The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity

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BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

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Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

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Mammalian telomeres end in a large duplex loop

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

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Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening

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Telomeres and telomerases as drug targets

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Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

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TERT regulates cell survival independent of telomerase enzymatic activity

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7 January 2021

Telomerase beyond telomeres

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7 January 2021

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

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The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

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Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

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Identification of Mad as a repressor of the human telomerase (hTERT) gene

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The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene

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In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells.

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E2F-1 represses transcription of the human telomerase reverse transcriptase gene

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A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer

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Retinoic acid inhibits telomerase activity and downregulates expression but does not affect splicing of hTERT: correlation with cell growth rate inhibition in an in vitro cervical carcinogenesis/multidrug-resistance model

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Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

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Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

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Telomeres shorten during ageing of human fibroblasts

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Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

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Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.

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Anti-apoptotic role of telomerase in pheochromocytoma cells

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The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis

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Telomerase protects developing neurons against DNA damage-induced cell death

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Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective

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7 January 2021

Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension

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The emerging role of telomerase in cardiac muscle cell growth and survival

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The cytotoxic effects of single-stranded telomere mimics on OMA-BL1 cells

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7 January 2021

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

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7 January 2021

10.1016/S0304-3835(02)00708-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12757979 AND SRC:MED&resulttype=core&format=json

3 November 2019

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