Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice (Q34178121)

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English	Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

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toll-like receptor

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

Philipp E. Scherer

12

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Philipp E Scherer

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Europe PubMed Central

PubMed publication ID

31 July 2017

10

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Markus R Wenk

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31 July 2017

Scott A Summers

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Scott A Summers

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31 July 2017

Deborah J. Clegg

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Deborah J Clegg

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31 July 2017

author name string

William L Holland

1

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31 July 2017

Benjamin T Bikman

2

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31 July 2017

Li-Ping Wang

3

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31 July 2017

Guan Yuguang

4

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31 July 2017

Katherine M Sargent

5

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31 July 2017

Sarada Bulchand

6

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31 July 2017

Trina A Knotts

7

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31 July 2017

Guanghou Shui

8

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31 July 2017

Michael J Pagliassotti

11

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31 July 2017

language of work or name

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publication date

1 April 2011

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31 July 2017

Journal of Clinical Investigation

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31 July 2017

121

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31 July 2017

5

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31 July 2017

1858-1870

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Europe PubMed Central

PubMed publication ID

31 July 2017

Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide

1 reference

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5 July 2018

Kdo2-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

1 reference

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5 July 2018

Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment

1 reference

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5 July 2018

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

1 reference

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5 July 2018

Toll-like receptor 4 modulates skeletal muscle substrate metabolism

1 reference

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5 July 2018

Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation

1 reference

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5 July 2018

Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling

1 reference

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5 July 2018

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

1 reference

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The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

1 reference

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5 July 2018

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

1 reference

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5 July 2018

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner

1 reference

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The geometry of leptin action in the brain: more complicated than a simple ARC.

1 reference

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5 July 2018

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

1 reference

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5 July 2018

Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.

1 reference

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5 July 2018

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Lipid mediators of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Disordered lipid metabolism and the pathogenesis of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Acid sphingomyelinase is required for lipid Raft TLR4 complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

TLR4 links innate immunity and fatty acid-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Ceramide-enriched membrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes

1 reference

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5 July 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

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5 July 2018

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Ceramide in the eukaryotic stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

5 July 2018

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation

1 reference

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5 July 2018

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

1 reference

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28 October 2018

Monitoring FoxO1 localization in chemically identified neurons

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28 October 2018

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

1 reference

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28 October 2018

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

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1 reference

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28 October 2018

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance

1 reference

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28 October 2018

Molecular disruption of hypothalamic nutrient sensing induces obesity

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28 October 2018

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues

1 reference

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28 October 2018

Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

1 reference

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28 October 2018

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids

1 reference

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28 October 2018

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Hypothalamic insulin signaling is required for inhibition of glucose production

1 reference

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28 October 2018

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083776

28 October 2018

Saturated fatty acids do not directly stimulate Toll-like receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramides: a new player in the inflammation-insulin resistance paradigm?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21490391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI43378

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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