The pathophysiologic role of alpha 4 integrins in vivo (Q34155588)

31 July 2017

1 reference

title

The pathophysiologic role of alpha 4 integrins in vivo (English)

1 reference

31 July 2017

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R R Lobb

1

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31 July 2017

M E Hemler

series ordinal

2

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31 July 2017

language of work or name

English

0 references

publication date

1 November 1994

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Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

94

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31 July 2017

issue

5

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31 July 2017

page(s)

1722-1728

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Endothelial-leukocyte adhesion molecules

31 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways

5 July 2018

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VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes

5 July 2018

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VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin

5 July 2018

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5 July 2018

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Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin

5 July 2018

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Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4 T lymphocytes

5 July 2018

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Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin

5 July 2018

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Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody

5 July 2018

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Stimulation of protein tyrosine phosphorylation in human B cells after ligation of the beta 1 integrin VLA-4

5 July 2018

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Requirements for leukocyte adhesion molecules in nephrotoxic nephritis

5 July 2018

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Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

5 July 2018

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Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1

5 July 2018

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Leukocyte-endothelial adhesion molecules

5 July 2018

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Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin

5 July 2018

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Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes

5 July 2018

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The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent

5 July 2018

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The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

5 July 2018

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Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1.

5 July 2018

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The alpha 4 beta 1/VCAM-1 adhesion pathway in physiology and disease

5 July 2018

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Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue

5 July 2018

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Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4

5 July 2018

1 reference

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Identification of a combinatorial epitope expressed by the integrin alpha 4 beta 1 heterodimer involved in the regulation of cell adhesion

5 July 2018

1 reference

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Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1).

5 July 2018

1 reference

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Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

5 July 2018

1 reference

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Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

5 July 2018

1 reference

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A new surface antigen on intraepithelial lymphocytes in the intestine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

VLA-4 mediates CD3-dependent CD4 T cell activation via the CS1 alternatively spliced domain of fibronectin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule

5 July 2018

1 reference

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Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage

5 July 2018

1 reference

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Structure-function analysis of the human integrin VLA-4 (alpha 4/beta 1). Correlation of proteolytic alpha 4 peptides with alpha 4 epitopes and sites of ligand interaction

5 July 2018

1 reference

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Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes

5 July 2018

1 reference

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Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules

5 July 2018

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Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells

5 July 2018

1 reference

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VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

5 July 2018

1 reference

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Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin

5 July 2018

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Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains

5 July 2018

1 reference

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Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

5 July 2018

1 reference

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Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response

5 July 2018

1 reference

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The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat.

28 October 2018

1 reference

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Activated T-cell adhesion to thrombospondin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins.

28 October 2018

1 reference

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Selective expression of integrin alpha 4 beta 7 on a subset of human CD4 memory T cells with Hallmarks of gut-trophism.

28 October 2018

1 reference

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Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

28 October 2018

1 reference

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Ligand-induced adhesion to activated endothelium and to vascular cell adhesion molecule-1 in lymphocytes transfected with the N-formyl peptide receptor.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294562

Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro

28 October 2018

1 reference

12 December 2020

Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin

1 reference

12 December 2020

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo

1 reference

12 December 2020

T lymphocyte migration to arthritic joints and dermal inflammation in the rat: differing migration patterns and the involvement of VLA-4

1 reference

12 December 2020

Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation

1 reference

12 December 2020

The evolving role of autologous peripheral stem cell transplantation following high-dose therapy for malignancies

1 reference

12 December 2020

Role of leukocyte adhesion molecules in complement-induced lung injury

1 reference

12 December 2020

Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes

1 reference

12 December 2020

The efficacy of LFA-1 and VLA-4 antibody treatment in rat vascularized cardiac allograft rejection

1 reference

12 December 2020

Expression of a protective intestinal immune response can be inhibited at three distinct sites by treatment with anti-alpha 4 integrin

1 reference

12 December 2020

Differential expression in rheumatoid synovium and synovial fluid of alpha 4 beta 7 integrin. A novel receptor for fibronectin and vascular cell adhesion molecule-1

1 reference

12 December 2020

Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo

1 reference

12 December 2020

Role of the endothelial adhesion molecule VCAM in murine cardiac allograft rejection

1 reference

12 December 2020

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1 reference

12 December 2020

Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin

1 reference

12 December 2020

Effect of anti-VCAM-1 and anti-VLA-4 monoclonal antibodies on cardiac allograft survival and response to soluble antigens in mice

1 reference

12 December 2020

Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs

1 reference

12 December 2020

Expanding roles for alpha 4 integrin and its ligands in development

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI117519

1 reference

31 July 2017

1 reference

31 July 2017

1 reference