mTOR signaling in glioblastoma: lessons learned from bench to bedside (Q34133033)

31 July 2017

1 reference

23 January 2021

mTOR signaling in glioblastoma: lessons learned from bench to bedside (English)

1 reference

protein-serine-threonine kinases

31 July 2017

1 reference

26 August 2020

1 reference

23 January 2021

1 reference

28 September 2019

1 reference

26 August 2020

intracellular signaling peptides and proteins

1 reference

23 January 2021

1 reference

2

Timothy F Cloughesy

1 reference

31 July 2017

David Akhavan

1

1 reference

31 July 2017

Paul S Mischel

series ordinal

3

1 reference

31 July 2017

language of work or name

1 reference

14 May 2010

1 reference

31 July 2017

1 August 2010

7 references

14 March 2019

3 April 2019

25 April 2019

28 September 2019

20 November 2019

26 August 2020

23 January 2021

8 references

31 July 2017

14 March 2019

3 April 2019

25 April 2019

28 September 2019

20 November 2019

26 August 2020

23 January 2021

12

1 reference

31 July 2017

issue

8

1 reference

31 July 2017

page(s)

882-889

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

31 July 2017

copyright license

7 references

14 March 2019

3 April 2019

25 April 2019

28 September 2019

20 November 2019

26 August 2020

on focus list of Wikimedia project

23 January 2021

ScienceSource

0 references

cites work

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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

5 July 2018

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5 July 2018

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

5 July 2018

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Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

5 July 2018

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PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

5 July 2018

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A drosophila model for EGFR-Ras and PI3K-dependent human glioma

5 July 2018

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Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation

5 July 2018

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EGFR signals to mTOR through PKC and independently of Akt in glioma

5 July 2018

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

5 July 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

5 July 2018

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Development of a novel mouse glioma model using lentiviral vectors

5 July 2018

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PI3K signaling in glioma--animal models and therapeutic challenges

5 July 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

5 July 2018

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

5 July 2018

1 reference

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

5 July 2018

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S6K1 plays a key role in glial transformation

5 July 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

5 July 2018

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Amino acids activate mTOR complex 1 via Ca2 /CaM signaling to hVps34.

5 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

5 July 2018

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

5 July 2018

1 reference

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mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

5 July 2018

1 reference

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5 July 2018

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

5 July 2018

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

5 July 2018

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

5 July 2018

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

5 July 2018

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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

5 July 2018

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Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways

5 July 2018

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New insight into BRAF mutations in cancer

5 July 2018

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5 July 2018

mTOR and cancer therapy

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mTOR and cancer: insights into a complex relationship

5 July 2018

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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells

5 July 2018

1 reference

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

5 July 2018

1 reference

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

TSC2 mediates cellular energy response to control cell growth and survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Targeting RAS signalling pathways in cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Mutations of the BRAF gene in human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten /- mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Gliomagenesis: genetic alterations and mouse models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples

5 July 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Epidermal growth factor receptor and Ink4a/Arf

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/NEUONC/NOQ052

The pharmacology of mTOR inhibition

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Genetic determinants of malignancy in a mouse model for oligodendroglioma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940679

28 October 2018

Identifiers

DOI

10.1093/NEUONC/NOQ052

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference