Cellular senescence as a tumor-protection mechanism: the essential role of counting (Q34132858)

31 July 2017

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title

Cellular senescence as a tumor-protection mechanism: the essential role of counting (English)

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31 July 2017

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1

Wright WE

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31 July 2017

Shay JW

2

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31 July 2017

publication date

1 February 2001

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Current Opinion in Genetics & Development

31 July 2017

published in

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31 July 2017

volume

11

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31 July 2017

issue

1

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31 July 2017

page(s)

98-103

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The serial cultivation of human diploid cell strains

31 July 2017

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Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang

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TRF2 Protects Human Telomeres from End-to-End Fusions

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In vivo loss of telomeric repeats with age in humans

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Telomeres shorten during ageing of human fibroblasts

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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

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Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

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Extension of life-span by introduction of telomerase into normal human cells

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Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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Creation of human tumour cells with defined genetic elements

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Transient expression of human telomerase extends the life span of normal human fibroblasts

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Cellular senescence: mitotic clock or culture shock?

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

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7 January 2021

N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts

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7 January 2021

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

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7 January 2021

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

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7 January 2021

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7 January 2021

Extended culture of mouse embryo cells without senescence: inhibition by serum.

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7 January 2021

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

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7 January 2021

The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review

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7 January 2021

Mitotic misregulation and human aging

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7 January 2021

Phospholipase D in cellular senescence

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7 January 2021

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

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7 January 2021

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

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7 January 2021

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

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7 January 2021

Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.

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7 January 2021

10.1016/S0959-437X(00)00163-5

Identifiers

DOI

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31 July 2017

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