TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype (Q34130168)

31 July 2017

title

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype (English)

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31 July 2017

0 references

1 reference

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Gianluca Storci

1

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Gabriele D'Uva

Gabriele D'Uva

4

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Pasquale Chieco

Pasquale Chieco

10

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Claudio Ceccarelli

Claudio Ceccarelli

8

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Mario Taffurelli

7

Mario Taffurelli

1 reference

31 July 2017

Pasquale Sansone

2

1 reference

31 July 2017

Sara Mari

3

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31 July 2017

Simona Tavolari

5

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31 July 2017

Tiziana Guarnieri

6

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31 July 2017

Donatella Santini

9

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31 July 2017

Kenneth B Marcu

11

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31 July 2017

Massimiliano Bonafè

12

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31 July 2017

publication date

1 November 2010

1 reference

Journal of Cellular Physiology

31 July 2017

published in

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31 July 2017

volume

225

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31 July 2017

issue

3

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31 July 2017

page(s)

682-691

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The hematopoietic stem cell niche: low in oxygen but a nice place to be.

31 July 2017

cites work

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The canonical NF-kappaB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

28 July 2018

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Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients

28 July 2018

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28 July 2018

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Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

28 July 2018

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Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype

28 July 2018

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28 July 2018

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Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1.

28 July 2018

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28 July 2018

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Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts.

28 July 2018

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The role of oxygen availability in embryonic development and stem cell function

28 July 2018

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Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

28 July 2018

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NF-kappa B genes have a major role in inflammatory breast cancer

28 July 2018

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Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

28 July 2018

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Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.

28 July 2018

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NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells

28 July 2018

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Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line

28 July 2018

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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

28 July 2018

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Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells

28 July 2018

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High-level JAG1 mRNA and protein predict poor outcome in breast cancer

28 July 2018

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The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia.

28 July 2018

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Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

28 July 2018

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Molecular definition of breast tumor heterogeneity

28 July 2018

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A mouse model of basal-like breast carcinoma with metaplastic elements

28 July 2018

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CD44 /CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

28 July 2018

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Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

28 July 2018

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Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor

28 July 2018

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Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers?

28 July 2018

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Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast

28 July 2018

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Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma

28 July 2018

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Gene expression profiling of breast cell lines identifies potential new basal markers.

28 July 2018

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

28 July 2018

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Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

28 July 2018

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High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

28 July 2018

1 reference

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Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

28 July 2018

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Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas.

28 July 2018

1 reference

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939957

Prospective identification of tumorigenic breast cancer cells

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939957

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939957

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939957

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939957

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

28 July 2018

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The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha

21 January 2018

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Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2.

21 January 2018

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The prognostic role of a gene signature from tumorigenic breast-cancer cells.

21 January 2018

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Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition

21 January 2018

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Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?

21 January 2018

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Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

21 January 2018

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Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice

21 January 2018

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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

21 January 2018

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The basal-like breast carcinoma phenotype is regulated by SLUG gene expression.

21 January 2018

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NF-kappaB activation in inflammatory breast cancer is associated with oestrogen receptor downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation

21 January 2018

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Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice

21 January 2018

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The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype

21 January 2018

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Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia

21 January 2018

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Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20509143

12 December 2020

inferred from PubMed ID database lookup

The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20509143

12 December 2020

inferred from PubMed ID database lookup

Tumour necrosis factor and cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20509143

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1002/JCP.22264

1 reference

release_tdcgqp2jubeptmdd2svcfgb25q

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tdcgqp2jubeptmdd2svcfgb25q

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2939957

1 reference

31 July 2017

1 reference