Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. (Q34120604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

review article

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title

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

0 references

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Susan J Duthie

series ordinal

1

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31 July 2017

publication date

11 June 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

Journal of Inherited Metabolic Disease

5 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

volume

34

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

101-109

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20544289 AND SRC:MED&resulttype=core&format=json

Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats

5 February 2020

cites work

1 reference

12 December 2020

Mechanisms of human DNA repair: an update

1 reference

12 December 2020

Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review

1 reference

12 December 2020

Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation

1 reference

12 December 2020

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression

1 reference

12 December 2020

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides

1 reference

12 December 2020

Serum folate and cancer mortality among U.S. adults: findings from the Third National Health and Nutritional Examination Survey linked mortality file

1 reference

12 December 2020

Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats

1 reference

12 December 2020

Effect of folate deficiency on mutations at the hprt locus in Chinese hamster ovary cells exposed to monofunctional alkylating agents

1 reference

12 December 2020

Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake

1 reference

12 December 2020

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

1 reference

12 December 2020

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

1 reference

12 December 2020

DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation

1 reference

12 December 2020

Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate

1 reference

12 December 2020

Folate and cancer: A review of the literature

1 reference

12 December 2020

Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa

1 reference

12 December 2020

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

1 reference

12 December 2020

Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues

1 reference

12 December 2020

Folic Acid for the Prevention of Colorectal Adenomas

1 reference

12 December 2020

Uracil misincorporation in human DNA detected using single cell gel electrophoresis.

1 reference

12 December 2020

Chemopreventive effects of dietary folate on intestinal polyps in Apc /-Msh2-/- mice

1 reference

12 December 2020

1 reference

12 December 2020

DNA methylation in folate deficiency: use of CpG methylase

1 reference

12 December 2020

Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in

1 reference

12 December 2020

8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways.

1 reference

12 December 2020

The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro.

1 reference

12 December 2020

Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma

1 reference

12 December 2020

DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats

1 reference

12 December 2020

The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon

1 reference

12 December 2020

Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model.

1 reference

12 December 2020

Folate depletion impairs DNA excision repair in the colon of the rat.

1 reference

12 December 2020

Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects

1 reference

12 December 2020

Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.

1 reference

12 December 2020

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

1 reference

12 December 2020

Colon cancer in Chile before and after the start of the flour fortification program with folic acid

1 reference

12 December 2020

Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis

1 reference

12 December 2020

The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice

1 reference

12 December 2020

Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma

1 reference

12 December 2020

Bone marrow cells from vitamin B12- and folate-deficient patients misincorporate uracil into DNA

1 reference

12 December 2020

Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid

1 reference

12 December 2020

A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer

1 reference

12 December 2020

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification

1 reference

12 December 2020

Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers

1 reference

12 December 2020

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

12 December 2020

Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer

1 reference

12 December 2020

Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene.

1 reference

12 December 2020

A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis

1 reference

12 December 2020

Folate Deficiency In Vitro Induces Uracil Misincorporation and DNA Hypomethylation and Inhibits DNA Excision Repair in Immortalized Normal Human Colon Epithelial Cells

1 reference

12 December 2020

Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

1 reference

12 December 2020

Analysis of uracil in DNA by gas chromatography-mass spectrometry

1 reference

12 December 2020

Endogenous DNA damage in humans: a review of quantitative data

1 reference

12 December 2020

Association between low dietary folate intake and suboptimal cellular DNA repair capacity

1 reference

12 December 2020

Role of deoxyuridine incorporation and DNA repair in the expression of human chromosomal fragile sites

1 reference

12 December 2020

Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei

1 reference

12 December 2020

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.

1 reference

12 December 2020

Folate intake and colorectal cancer risk: a meta-analytical approach

1 reference

12 December 2020

Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial

1 reference

12 December 2020

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

1 reference

12 December 2020

A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis

1 reference

12 December 2020

Cancer incidence and mortality after treatment with folic acid and vitamin B12.

1 reference

12 December 2020

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

1 reference

12 December 2020

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

1 reference

12 December 2020

DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro

1 reference

12 December 2020

Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation

1 reference

12 December 2020

Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations

1 reference

12 December 2020

Folate and colorectal cancer: an evidence-based critical review

1 reference

12 December 2020

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.

1 reference

12 December 2020

DNA mismatch repair genes and their association with colorectal cancer (Review).

1 reference

12 December 2020

Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon

1 reference

12 December 2020

Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats

1 reference

12 December 2020

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

1 reference

12 December 2020

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

1 reference

12 December 2020

Homocysteine lowering and cardiovascular events after acute myocardial infarction

1 reference

12 December 2020

Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation

1 reference

12 December 2020

The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today

1 reference

12 December 2020

Epidemiologic studies of folate and colorectal neoplasia: a review

1 reference

12 December 2020

Increased uracil misincorporation in lymphocytes from folate-deficient rats

1 reference

12 December 2020

Nucleotide excision repair and human syndromes

1 reference

12 December 2020

The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses

1 reference

12 December 2020

Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults

1 reference

12 December 2020

Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro

1 reference

12 December 2020

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

1 reference

12 December 2020

Folic acid and risk of prostate cancer: results from a randomized clinical trial

1 reference

12 December 2020

Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women

1 reference

12 December 2020