86Rb efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization (Q34109947)

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English	86Rb efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization	scientific article

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7 February 2020

86Rb efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization (English)

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7 February 2020

desensitization

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3

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7 February 2020

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Michael J Marks

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7 February 2020

Natalie M Meinerz

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7 February 2020

Allan C Collins

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7 February 2020

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30 June 2010

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7 February 2020

Biochemical Pharmacology

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7 February 2020

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7 February 2020

8

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7 February 2020

1238-1251

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7 February 2020

Varenicline in smoking cessation

1 reference

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Varenicline: a pharmacoeconomic review of its use as an aid to smoking cessation

1 reference

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5 July 2018

Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway.

1 reference

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Nicotine and behavioral sensitization

1 reference

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Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain

1 reference

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5 July 2018

Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression

1 reference

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5 July 2018

Roles of accessory subunits in alpha4beta2(*) nicotinic receptors

1 reference

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It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

1 reference

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Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation

1 reference

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5 July 2018

Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb efflux with high and low sensitivity to stimulation by acetylcholine

1 reference

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Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation

1 reference

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Role of the agonist binding site in up-regulation of neuronal nicotinic alpha4beta2 receptors

1 reference

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5 July 2018

Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors

1 reference

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Rat nicotinic acetylcholine receptor alpha2beta2 channels: comparison of functional properties with alpha4beta2 channels in Xenopus oocytes

1 reference

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5 July 2018

Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

5 July 2018

Human alpha4beta2 acetylcholine receptors formed from linked subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

5 July 2018

Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors

1 reference

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5 July 2018

Desensitization of neuronal nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

5 July 2018

Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.

1 reference

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5 July 2018

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse

1 reference

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Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1 reference

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5 July 2018

Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition

1 reference

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Effect of smoking history on [3H]nicotine binding in human postmortem brain

1 reference

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5 July 2018

Influence of Subunit Composition on Desensitization of Neuronal Acetylcholine Receptors at Low Concentrations of Nicotine

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Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

5 July 2018

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1 reference

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5 July 2018

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1 reference

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5 July 2018

In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs

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5 July 2018

Kinetics and mechanism of L-[3H]nicotine binding to putative high affinity receptor sites in rat brain.

1 reference

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5 July 2018

Nicotinic binding sites in rat and mouse brain: comparison of acetylcholine, nicotine, and alpha-bungarotoxin

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Evidence that tobacco smoking increases the density of (-)-[3H]nicotine binding sites in human brain

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5 July 2018

Purification of L-[3H]nicotine eliminates low affinity binding

1 reference

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5 July 2018

An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment

1 reference

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5 July 2018

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment

1 reference

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5 July 2018

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1 reference

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5 July 2018

Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo

1 reference

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28 October 2018

Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.

1 reference

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28 October 2018

Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers

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Stoichiometry and pharmacology of two human alpha4beta2 nicotinic receptor types

1 reference

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28 October 2018

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine

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28 October 2018

Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment

1 reference

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28 October 2018

Subsets of acetylcholine-stimulated 86Rb efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment

1 reference

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1 reference

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28 October 2018

Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography

1 reference

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Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas.

1 reference

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28 October 2018

Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb( ) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

1 reference

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28 October 2018

Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation

1 reference

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28 October 2018

Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Four pharmacologically distinct subtypes of alpha4beta2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes

1 reference

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28 October 2018

Dose-response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors

1 reference

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28 October 2018

Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific

1 reference

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28 October 2018

Effects of chronic nicotine infusion on kinetics of high-affinity nicotine binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935307

28 October 2018

Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons.

1 reference

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28 October 2018

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

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28 October 2018

Pharmacological and null mutation approaches reveal nicotinic receptor diversity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the desensitization produced by acetylcholine at the motor end-plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic agonists differ in activation and desensitization of 86Rb efflux from mouse thalamic synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of nicotinic receptor function after chronic nicotine infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desensitization of nicotine-stimulated 86Rb efflux from mouse brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20599770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.BCP.2010.06.040

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20599770 AND SRC:MED&resulttype=core&format=json

7 February 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20599770 AND SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20599770 AND SRC:MED&resulttype=core&format=json

7 February 2020

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