Diacylglycerol-mediated insulin resistance (Q34109119)

31 July 2017

title

Diacylglycerol-mediated insulin resistance (English)

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31 July 2017

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2

Gerald I Shulman

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31 July 2017

Derek M Erion

1

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31 July 2017

language of work or name

English

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publication date

1 April 2010

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31 July 2017

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31 July 2017

volume

16

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31 July 2017

issue

4

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31 July 2017

page(s)

400-402

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Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

31 July 2017

cites work

1 reference

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Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

5 July 2018

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The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

5 July 2018

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Inflammation and endoplasmic reticulum stress in obesity and diabetes

5 July 2018

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5 July 2018

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Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

5 July 2018

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

5 July 2018

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Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

5 July 2018

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

5 July 2018

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Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

5 July 2018

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Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

5 July 2018

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Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients

5 July 2018

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Inflammation and metabolic disorders

5 July 2018

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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

5 July 2018

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5 July 2018

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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

5 July 2018

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

5 July 2018

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Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

5 July 2018

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Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

5 July 2018

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PKC-theta knockout mice are protected from fat-induced insulin resistance

5 July 2018

1 reference

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

5 July 2018

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Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

5 July 2018

1 reference

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

5 July 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

5 July 2018

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Obesity is associated with macrophage accumulation in adipose tissue

5 July 2018

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Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

5 July 2018

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

5 July 2018

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5 July 2018

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Immunoassay of endogenous plasma insulin in man

28 October 2018

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

5 July 2018

1 reference

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Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy

5 July 2018

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Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

5 July 2018

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

5 July 2018

1 reference

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The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

5 July 2018

1 reference

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Contributions of gluconeogenesis to glucose production in the fasted state

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Mechanism of free fatty acid-induced insulin resistance in humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Insulin resistance. Prosperity's plague.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3730126

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

28 October 2018

1 reference

12 December 2020

The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

1 reference

12 December 2020

Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

1 reference

12 December 2020

Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

1 reference

Crossref

https://api.crossref.org/works/10.1038/NM0410-400

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM0410-400

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference

31 July 2017

1 reference