Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development (Q34108757)

31 July 2017

title

Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development (English)

1 reference

cerebral cavernous malformation 3

31 July 2017

main subject

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5

Titus J Boggon

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31 July 2017

Yun He

1

1 reference

31 July 2017

Haifeng Zhang

2

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31 July 2017

Luyang Yu

3

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31 July 2017

Murat Gunel

4

1 reference

31 July 2017

Hong Chen

6

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31 July 2017

Wang Min

7

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31 July 2017

publication date

6 April 2010

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31 July 2017

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31 July 2017

volume

3

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31 July 2017

issue

116

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31 July 2017

page(s)

ra26

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CCM2 mediates death signaling by the TrkA receptor tyrosine kinase

31 July 2017

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Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

5 July 2018

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5 July 2018

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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

5 July 2018

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5 July 2018

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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

5 July 2018

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5 July 2018

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CCM2 expression parallels that of CCM1.

5 July 2018

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5 July 2018

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5 July 2018

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Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.

5 July 2018

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5 July 2018

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CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

5 July 2018

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Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

5 July 2018

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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction

5 July 2018

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Mutations within the MGC4607 gene cause cerebral cavernous malformations

5 July 2018

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Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

5 July 2018

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Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

5 July 2018

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Endothelial cells require STAT3 for protection against endotoxin-induced inflammation

5 July 2018

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Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway

5 July 2018

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Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

5 July 2018

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Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult

5 July 2018

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VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

5 July 2018

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Rap1 GTPase regulation of adherens junction positioning and cell adhesion.

5 July 2018

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Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo

5 July 2018

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KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

5 July 2018

1 reference

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Mekk3 is essential for early embryonic cardiovascular development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052863

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052863

Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052863

Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.

5 July 2018

1 reference

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Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

5 July 2018

1 reference

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

5 July 2018

1 reference

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Cerebral cavernous malformations. Incidence and familial occurrence

5 July 2018

1 reference

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ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

5 July 2018

1 reference

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Genotype-phenotype correlations in cerebral cavernous malformations patients

28 October 2018

1 reference

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Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

28 October 2018

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Clinical impact of CCM mutation detection in familial cavernous angioma

28 October 2018

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santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish

28 October 2018

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Nestin-Cre mediated deletion of Pitx2 in the mouse

28 October 2018

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Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development

28 October 2018

1 reference

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A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

28 October 2018

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Krev1 interaction trapped-1/cerebral cavernous malformation-1 protein expression during early angiogenesis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052863

KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex

28 October 2018

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Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

28 October 2018

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Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells

28 October 2018

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High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice

28 October 2018

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12 December 2020

[131 cases of cavernous angioma (cavernomas) of the CNS, discovered by retrospective analysis of 24,535 autopsies]

1 reference

12 December 2020

A gene responsible for cavernous malformations of the brain maps to chromosome 7q

1 reference

12 December 2020

MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis

1 reference

12 December 2020

PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit

1 reference

12 December 2020

10.1126/SCISIGNAL.2000722

Identifiers

DOI

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31 July 2017

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31 July 2017

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