Defining the pathway to insulin-like growth factor system targeting in cancer (Q34107722)

31 July 2017

1 reference

title

Defining the pathway to insulin-like growth factor system targeting in cancer (English)

1 reference

31 July 2017

1 reference

Steven A Rosenzweig

1

1 reference

31 July 2017

Hanudatta S Atreya

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

23 June 2010

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31 July 2017

published in

Biochemical Pharmacology

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31 July 2017

volume

80

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31 July 2017

issue

8

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31 July 2017

page(s)

1115-1124

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High-yield bacterial expression and structural characterization of recombinant human insulin-like growth factor binding protein-2

31 July 2017

cites work

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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

5 July 2018

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IGF-1 receptor inhibitors in clinical trials--early lessons

5 July 2018

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

5 July 2018

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Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials

5 July 2018

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Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes.

5 July 2018

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5 July 2018

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5 July 2018

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Targeting insulin and insulin-like growth factor signalling in oncology

5 July 2018

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Vitamin D and intervention trials in prostate cancer: from theory to therapy

5 July 2018

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Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 5.

5 July 2018

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Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

5 July 2018

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5 July 2018

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Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib ('Iressa') response and resistance.

5 July 2018

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5 July 2018

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Insulin-like growth factor binding protein 2 promotes glioma development and progression

5 July 2018

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5 July 2018

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The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

5 July 2018

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IGF-binding protein-2 protects against the development of obesity and insulin resistance

5 July 2018

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Disrupting insulin-like growth factor signaling as a potential cancer therapy

5 July 2018

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Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells.

5 July 2018

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Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)

5 July 2018

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Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma

5 July 2018

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Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis

5 July 2018

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Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins

5 July 2018

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Paradoxical effects of the phage display-derived peptide antagonist IGF-F1-1 on insulin-like growth factor-1 receptor signaling

5 July 2018

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Calcium plus vitamin D supplementation and the risk of colorectal cancer

5 July 2018

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Targeting insulin-like growth factor pathways.

5 July 2018

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EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells

5 July 2018

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Structural basis for the regulation of insulin-like growth factors by IGF binding proteins

5 July 2018

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What's new in the IGF-binding proteins?

5 July 2018

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5 July 2018

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IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407.

5 July 2018

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Insulin-like growth factor binding protein (IGFBP) signalling

5 July 2018

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5 July 2018

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The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane

5 July 2018

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Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.

5 July 2018

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Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

5 July 2018

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Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function

5 July 2018

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Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture

5 July 2018

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Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling

5 July 2018

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Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

5 July 2018

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Use of mutagenesis to probe IGF-binding protein structure/function relationships.

5 July 2018

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Recombinant DNA technology in the treatment of diabetes: insulin analogs

5 July 2018

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The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5

5 July 2018

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

5 July 2018

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5 July 2018

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5 July 2018

The Hallmarks of Cancer

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The insulin-like growth factor-binding protein (IGFBP) superfamily

5 July 2018

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5 July 2018

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Elevated glucose increases mesangial cell sensitivity to insulin-like growth factor I.

5 July 2018

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Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions

5 July 2018

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polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice

5 July 2018

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Retinoic Acid Inhibits Cell Growth in HPV Negative Cervical Carcinoma Cells by Induction of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Secretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

The IRS-signalling system during insulin and cytokine action

5 July 2018

1 reference

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Gene expression profiles in normal and cancer cells

5 July 2018

1 reference

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Recombinant proteins for therapy

5 July 2018

1 reference

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Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

5 July 2018

1 reference

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Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

5 July 2018

1 reference

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Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis

5 July 2018

1 reference

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Induction of the growth inhibitor IGF-binding protein 3 by p53

5 July 2018

1 reference

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Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence

5 July 2018

1 reference

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Parental imprinting of the mouse insulin-like growth factor II gene.

5 July 2018

1 reference

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Variables Controlling the Secretion of Insulin-Like Growth Factor Binding Protein-2 in Normal Human Subjects*

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Two Insulin-Like Growth Factor (IGF)-Binding Proteins Are Responsible for the Selective Affinity for IGF-II of Cerebrospinal Fluid Binding Proteins*

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast

5 July 2018

1 reference

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Predictive biomarkers for targeting insulin-like growth factor-I (IGF-I) receptor.

5 July 2018

1 reference

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Does diabetes therapy influence the risk of cancer?

28 October 2018

1 reference

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Ready for a comeback of natural products in oncology

28 October 2018

1 reference

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Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft

28 October 2018

1 reference

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

28 October 2018

1 reference

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IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Insulin-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934757

IGF-1: old growth factor shines as new drug target

28 October 2018

1 reference

12 December 2020

Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications

1 reference

12 December 2020

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

1 reference

12 December 2020

Synthesis and characterization of insulin-like growth factor (IGF)-1 photoprobes selective for the IGF-binding proteins (IGFBPS). photoaffinity labeling of the IGF-binding domain on IGFBP-2

1 reference

12 December 2020

Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?

1 reference

12 December 2020

All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway

1 reference

12 December 2020

Efficacy and safety of mecasermin rinfabate

1 reference

12 December 2020

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

1 reference

12 December 2020

1 reference

12 December 2020

10.1016/J.BCP.2010.06.013

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference