Alternative lengthening of telomeres: models, mechanisms and implications (Q34107386)

31 July 2017

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title

Alternative lengthening of telomeres: models, mechanisms and implications (English)

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31 July 2017

1

Anthony J Cesare

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31 July 2017

Roger R Reddel

2

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31 July 2017

publication date

30 March 2010

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31 July 2017

published in

Nature Reviews Genetics

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31 July 2017

volume

11

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31 July 2017

issue

5

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31 July 2017

page(s)

319-330

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

31 July 2017

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A DNA damage checkpoint response in telomere-initiated senescence

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Telomeres shorten during ageing of human fibroblasts

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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Mammalian telomeres end in a large duplex loop

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The role of senescence and immortalization in carcinogenesis

31 March 2020

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A survey of telomerase activity in human cancer

31 March 2020

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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

31 March 2020

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Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme.

31 March 2020

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Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

31 March 2020

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Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

31 March 2020

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The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression

31 March 2020

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Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

31 March 2020

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A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

31 March 2020

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Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops

31 March 2020

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Homologous recombination generates T-loop-sized deletions at human telomeres

31 March 2020

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Unusual telomeric DNAs in human telomerase-negative immortalized cells

31 March 2020

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DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

31 March 2020

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Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines

31 March 2020

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Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity

31 March 2020

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Telomere elongation in immortal human cells without detectable telomerase activity

31 March 2020

2 references

31 March 2020

12 December 2020

Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells

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Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

31 March 2020

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Telomeric circles: universal players in telomere maintenance?

31 March 2020

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Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.

31 March 2020

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Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.

31 March 2020

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Control of telomere length by a trimming mechanism that involves generation of t-circles

31 March 2020

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A novel mechanism for telomere size control in Saccharomyces cerevisiae

31 March 2020

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An alternative pathway for yeast telomere maintenance rescues est1- senescence

31 March 2020

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

31 March 2020

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Telomere maintenance by recombination in human cells.

31 March 2020

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Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

31 March 2020

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Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

31 March 2020

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Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities

31 March 2020

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Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

31 March 2020

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Molecular mechanisms of sister-chromatid exchange

31 March 2020

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Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

31 March 2020

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The first molecular details of ALT in human tumor cells

31 March 2020

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Telomere exchange and asymmetric segregation of chromosomes can account for the unlimited proliferative potential of ALT cell populations.

31 March 2020

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Identification of sister chromatids by DNA template strand sequences

31 March 2020

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Alternative lengthening of telomeres in mammalian cells

31 March 2020

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Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

31 March 2020

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Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

31 March 2020

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Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres

31 March 2020

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

31 March 2020

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

31 March 2020

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Multiple roles for MRE11 at uncapped telomeres

31 March 2020

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Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2

31 March 2020

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Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

31 March 2020

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The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

31 March 2020

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Break-induced replication and recombinational telomere elongation in yeast

31 March 2020

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The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination

31 March 2020

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FEN1 contributes to telomere stability in ALT-positive tumor cells

31 March 2020

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Telomere recombination requires the MUS81 endonuclease.

31 March 2020

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A role for monoubiquitinated FANCD2 at telomeres in ALT cells

31 March 2020

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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

31 March 2020

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Flap endonuclease 1 contributes to telomere stability

31 March 2020

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Flap endonuclease 1: a central component of DNA metabolism

31 March 2020

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Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies

31 March 2020

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A novel telomere structure in a human alternative lengthening of telomeres cell line

31 March 2020

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Structural and functional relationships of the XPF/MUS81 family of proteins

31 March 2020

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Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights

31 March 2020

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The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

31 March 2020

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TRF2 Protects Human Telomeres from End-to-End Fusions

31 March 2020

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Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line

31 March 2020

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Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break

31 March 2020

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

31 March 2020

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SGS1 is required for telomere elongation in the absence of telomerase

31 March 2020

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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

31 March 2020

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Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

31 March 2020

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Functional dissection of human and mouse POT1 proteins

31 March 2020

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Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

31 March 2020

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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

31 March 2020

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POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination

31 March 2020

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p53 binds telomeric single strand overhangs and t-loop junctions in vitro

31 March 2020

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The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats

31 March 2020

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TRF2 promotes, remodels and protects telomeric Holliday junctions

31 March 2020

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Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.

31 March 2020

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Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

31 March 2020

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The epigenetic regulation of mammalian telomeres

31 March 2020

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Epigenetic regulation of telomeres in human cancer.

31 March 2020

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Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

31 March 2020

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Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells.

31 March 2020

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DNA damage foci at dysfunctional telomeres

31 March 2020

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DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

31 March 2020

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A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

31 March 2020

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Human RAP1 inhibits non-homologous end joining at telomeres

31 March 2020

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

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Different telomere damage signaling pathways in human and mouse cells

31 March 2020

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Telomere uncapping and alternative lengthening of telomeres

31 March 2020

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

31 March 2020

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

31 March 2020

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

31 March 2020

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Visualizing telomere dynamics in living mammalian cells using PNA probes

31 March 2020

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DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA.

31 March 2020

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A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT.

31 March 2020

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Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins

31 March 2020

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Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.

31 March 2020

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

31 March 2020

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Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body

31 March 2020

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Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

31 March 2020

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Telomere dynamics in an immortal human cell line

31 March 2020

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12 December 2020

A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

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12 December 2020

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

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12 December 2020

Altered distribution of the promyelocytic leukemia-associated protein is associated with cellular senescence.

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12 December 2020

ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle.

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12 December 2020

Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres

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12 December 2020

The frequency of homologous recombination in human ALT cells

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12 December 2020

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body

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12 December 2020

Identifiers

DOI

10.1038/NRG2763

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Dimensions Publication ID

31 July 2017

1025611349

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