Development of inhibitors for protein tyrosine kinases (Q34103669)

31 July 2017

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title

Development of inhibitors for protein tyrosine kinases (English)

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31 July 2017

Al-Obeidi FA

1

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31 July 2017

Lam KS

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 November 2000

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31 July 2017

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31 July 2017

volume

19

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31 July 2017

issue

49

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31 July 2017

page(s)

5690-5701

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Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design

31 July 2017

cites work

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Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin.

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Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice

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A solid-phase assay for the determination of protein tyrosine kinase activity of c-src using scintillating microtitration plates

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Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor

21 January 2018

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RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

21 January 2018

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Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin

21 January 2018

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Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-Genistein in patients with B-lineage lymphoid malignancies

21 January 2018

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Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs

21 January 2018

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Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers

21 January 2018

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Phase I and pharmacologic study of the tyrosine kinase inhibitor SU101 in patients with advanced solid tumors

21 January 2018

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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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21 January 2018

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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

21 January 2018

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SH2-directed ligands of the Lck tyrosine kinase.

21 January 2018

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Protein tyrosine kinase inhibitors as novel therapeutic agents

21 January 2018

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Tyrosine kinase inhibition: an approach to drug development

21 January 2018

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Different early effets of tyrphostin AG957 and geldanamycins on mitogen-activated protein kinase and p120cbl phosphorylation in anti CD-3-stimulated T-lymphoblasts

21 January 2018

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Identification of GIYWHHY as a novel peptide substrate for human p60c-src protein tyrosine kinase

21 January 2018

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Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

21 January 2018

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A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cellsin vitro andin vivo

21 January 2018

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In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022.

21 January 2018

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

21 January 2018

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

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Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.

21 January 2018

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Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

21 January 2018

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Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

21 January 2018

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Chromosomal translocations in human cancer.

21 January 2018

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Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity

21 January 2018

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Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

21 January 2018

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Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats

21 January 2018

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A tyrosine kinase profile of prostate carcinoma

21 January 2018

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The pathogenesis of atherosclerosis: a perspective for the 1990s

21 January 2018

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Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

21 January 2018

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

21 January 2018

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Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display

21 January 2018

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Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

21 January 2018

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Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners

21 January 2018

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Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

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Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor

21 January 2018

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

21 January 2018

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Molecular scaffold-based design and comparison of combinatorial libraries focused on the ATP-binding site of protein kinases

21 January 2018

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Herceptin (trastuzamab) in advanced breast cancer

21 January 2018

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Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors

21 January 2018

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Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases

21 January 2018

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Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases

21 January 2018

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Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression

21 January 2018

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4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase

21 January 2018

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Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

Tyrosine kinase inhibitors as antiproliferative agents against an estrogen-dependent breast cancer cell line in vitro

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

Comparison of the intrinsic kinase activity and substrate specificity of c-Abl and Bcr-Abl

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation

21 January 2018

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

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21 January 2018

One gene—four syndromes

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Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

21 January 2018

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7 January 2021

Measurement of the protein tyrosine kinase activity of c-src using time-resolved fluorometry of europium chelates

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

The development and therapeutic potential of protein kinase inhibitors

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Overexpression of transforming growth factor alpha in psoriatic epidermis

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Combinatorial chemistry as a tool for drug discovery

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-gamma 1

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

The Growth Regulation of Keratinocytes

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Protein tyrosine kinases and cancer

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https://api.crossref.org/works/10.1038/SJ.ONC.1203926

7 January 2021

Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases.

1 reference

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7 January 2021

A 58-year-old man with sarcoidosis complicated by focal crescentic glomerulonephritis

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7 January 2021

Nonphosphorylatable tyrosine surrogates. Implications for protein kinase inhibitor design

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7 January 2021

Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus

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7 January 2021

Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding

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7 January 2021

Protein Phosphorylation and Dephosphorylation in Physiologic and Oncologic Processes

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7 January 2021

Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors

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Clinical pharmacology of UCN-01: initial observations and comparison to preclinical models

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Src homology-2 domains: structure, mechanisms, and drug discovery

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A Homogeneous, Fluorescence Polarization Assay for Src-Family Tyrosine Kinases

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Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3

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Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203926

1 reference

Dimensions Publication ID

31 July 2017

1046599002

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