Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis (Q34101296)

31 July 2017

title

Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis (English)

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31 July 2017

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Sang-Heng Kok

1

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31 July 2017

Kuo-Liang Hou

2

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31 July 2017

Chi-Yuan Hong

3

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31 July 2017

Juo-Song Wang

4

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31 July 2017

Po-Chin Liang

5

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Cheng-Chi Chang

6

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31 July 2017

Michael Hsiao

7

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31 July 2017

Hsiang Yang

8

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31 July 2017

Eddie Hsiang-Hua Lai

9

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Sze-Kwan Lin

10

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31 July 2017

publication date

26 February 2010

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31 July 2017

published in

Arthritis & Rheumatology

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volume

63

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31 July 2017

issue

4

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31 July 2017

page(s)

1010-1020

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Evidence that cytokines play a role in rheumatoid arthritis

31 July 2017

cites work

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The role of the interleukin‐6 family of cytokines in inflammatory arthritis and bone turnover

21 January 2018

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MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor.

21 January 2018

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All in the CCN family: essential matricellular signaling modulators emerge from the bunker

21 January 2018

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The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts

21 January 2018

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Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

21 January 2018

1 reference

Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets.

21 January 2018

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Simvastatin as a novel strategy to alleviate periapical lesions

21 January 2018

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Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins

21 January 2018

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A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis

21 January 2018

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Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

21 January 2018

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Anti-inflammatory effects of statins: clinical evidence and basic mechanisms

21 January 2018

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Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis

21 January 2018

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis

21 January 2018

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Assessment of the efficacy of different statins in murine collagen-induced arthritis

21 January 2018

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5' flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus

21 January 2018

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Promoter function and structure of the growth factor-inducible immediate early gene cyr61

21 January 2018

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Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells

21 January 2018

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Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts

21 January 2018

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Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation

21 January 2018

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Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis.

21 January 2018

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Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis.

21 January 2018

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IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis

21 January 2018

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Expression, purification, and functional testing of recombinant CYR61/CCN1.

21 January 2018

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Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures

21 January 2018

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Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways

21 January 2018

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Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma

21 January 2018

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Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy?

21 January 2018

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The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5.

21 January 2018

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The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

21 January 2018

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The safety of statins in clinical practice

21 January 2018

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New insights into the pharmacodynamic and pharmacokinetic properties of statins.

21 January 2018

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Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.27433

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31 July 2017

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