Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses (Q34096983)

31 July 2017

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title

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses (English)

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31 July 2017

5

Ian A Wilson

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31 July 2017

4

Jeffery W Kelly

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31 July 2017

Stephen Connelly

1

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31 July 2017

Sungwook Choi

series ordinal

2

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31 July 2017

Steven M Johnson

series ordinal

3

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31 July 2017

language of work or name

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3 February 2010

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Current Opinion in Structural Biology

31 July 2017

published in

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31 July 2017

volume

20

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31 July 2017

issue

1

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31 July 2017

page(s)

54-62

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A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

31 July 2017

cites work

1 reference

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Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

5 July 2018

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Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

5 July 2018

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Iodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis Inhibitors

5 July 2018

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Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

5 July 2018

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Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

5 July 2018

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Iodination of salicylic acid improves its binding to transthyretin

5 July 2018

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Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

5 July 2018

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5 July 2018

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Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

5 July 2018

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Kinetic assay for high-throughput screening of in vitro transthyretin amyloid fibrillogenesis inhibitors.

5 July 2018

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Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

5 July 2018

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Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor

5 July 2018

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Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

5 July 2018

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Halogen bonds in biological molecules

5 July 2018

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Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

5 July 2018

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Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

5 July 2018

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Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

5 July 2018

1 reference

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Non-steroidal anti-inflammatory drugs and the continuum of renal dysfunction

5 July 2018

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Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

5 July 2018

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Therapeutic strategies for human amyloid diseases

5 July 2018

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Comparison of binding interactions of dibromoflavonoids with transthyretin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites

5 July 2018

1 reference

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Structure of a new polymorphic monoclinic form of human transthyretin at 3 A resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Rational design of potent human transthyretin amyloid disease inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

5 July 2018

1 reference

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The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP

5 July 2018

1 reference

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Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

5 July 2018

1 reference

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Transthyretin Quaternary and Tertiary Structural Changes Facilitate Misassembly into Amyloid

5 July 2018

1 reference

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Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans

5 July 2018

1 reference

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The crystal structure of transthyretin from chicken

5 July 2018

1 reference

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Crystal structure of the transthyretin--retinoic-acid complex

5 July 2018

1 reference

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Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex

5 July 2018

1 reference

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The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

The binding of xanthone derivatives to transthyretin.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Kinetic stabilization of an oligomeric protein by a single ligand binding event

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Mechanisms of molecular recognition: crystal structure analysis of human and rat transthyretin inhibitor complexes

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Neurodegenerative disease: amyloid pores from pathogenic mutations

28 October 2018

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Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

28 October 2018

1 reference

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The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation

28 October 2018

1 reference

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Binding of thyroid hormones and analogues to the human plasma protein prealbumin.

28 October 2018

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The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Flavonoid Administration Immediately Displaces Thyroxine (T4) from Serum Transthyretin, Increases Serum Free T4, and Decreases Serum Thyrotropin in the Rat*

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830738

Discovering transthyretin amyloid fibril inhibitors by limited screening

28 October 2018

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12 December 2020

Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin

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12 December 2020

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors

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12 December 2020

Strjcture of human plasma prealbumin at 2-5 A resolution. A preliminary report on the polypeptide chain conformation, quaternary structure and thyroxine binding

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12 December 2020

10.1016/J.SBI.2009.12.009

Identifiers

DOI

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31 July 2017

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31 July 2017

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