Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. (Q34091331)

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17 January 2020

title

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice (English)

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17 January 2020

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0 references

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Massimiliano Cadamuro

5

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17 January 2020

author name string

Carlo Spirli

1

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17 January 2020

Stefano Okolicsanyi

2

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17 January 2020

Romina Fiorotto

3

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17 January 2020

Luca Fabris

4

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17 January 2020

Silvia Lecchi

6

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17 January 2020

Xin Tian

7

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17 January 2020

Stefan Somlo

8

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17 January 2020

Mario Strazzabosco

9

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17 January 2020

language of work or name

English

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publication date

1 May 2010

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17 January 2020

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17 January 2020

volume

51

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17 January 2020

issue

5

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17 January 2020

page(s)

1778-1788

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ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice

17 January 2020

cites work

1 reference

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Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

28 July 2018

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Antitumoral activity of rapamycin mediated through inhibition of HIF-1alpha and VEGF in hepatocellular carcinoma

28 July 2018

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28 July 2018

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Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease

28 July 2018

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Sirolimus reduces polycystic liver volume in ADPKD patients

28 July 2018

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Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

28 July 2018

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

28 July 2018

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AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells

28 July 2018

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Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

28 July 2018

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Estrogens and the pathophysiology of the biliary tree

28 July 2018

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Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases

28 July 2018

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

28 July 2018

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TOR signaling in growth and metabolism

28 July 2018

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The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis

28 July 2018

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Pathophysiology of cholangiopathies

28 July 2018

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

28 July 2018

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Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells

28 July 2018

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Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2 signaling

28 July 2018

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Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.

21 January 2018

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Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

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A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action

21 January 2018

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Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

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Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis.

21 January 2018

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Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion.

21 January 2018

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Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2 and cAMP signaling

21 January 2018

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Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

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Activation of the IGF1 System Characterizes Cholangiocyte Survival During Progression of Primary Biliary Cirrhosis

21 January 2018

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Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20131403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20131403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Vascular endothelial growth factor (VEGF), VEGF receptors expression and microvascular density in benign and malignant thyroid diseases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20131403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/HEP.23511

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20131403 AND SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20131403 AND SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

20131403

1 reference