Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway (Q34085728)

30 July 2017

title

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway (English)

1 reference

30 July 2017

3

Mark Kester

1 reference

30 July 2017

2

Todd E Fox

1 reference

30 July 2017

Jeremiah N Winter

1

1 reference

30 July 2017

Leonard S Jefferson

series ordinal

4

1 reference

30 July 2017

Scot R Kimball

series ordinal

5

1 reference

30 July 2017

publication date

28 April 2010

1 reference

American Journal of Physiology - Cell Physiology

30 July 2017

published in

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30 July 2017

volume

299

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30 July 2017

issue

2

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30 July 2017

page(s)

C335-44

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mTOR signaling at a glance

30 July 2017

cites work

1 reference

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5 July 2018

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Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Rheb binds and regulates the mTOR kinase

5 July 2018

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

5 July 2018

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Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

5 July 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

5 July 2018

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Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

5 July 2018

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

5 July 2018

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

5 July 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

5 July 2018

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

5 July 2018

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Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells

5 July 2018

1 reference

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Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

5 July 2018

1 reference

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Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway

5 July 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

5 July 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

5 July 2018

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

5 July 2018

1 reference

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

5 July 2018

1 reference

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A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

5 July 2018

1 reference

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

5 July 2018

1 reference

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

5 July 2018

1 reference

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Lysophosphatidic acid: receptors, signaling and survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Lipid phosphate phosphatase-1 and Ca2 control lysophosphatidate signaling through EDG-2 receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme

5 July 2018

1 reference

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Phosphatidic acid increases intracellular free Ca2 and cardiac contractile force

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells

5 July 2018

1 reference

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Serum phospholipases A2 in inflammatory diseases

5 July 2018

1 reference

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Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells

5 July 2018

1 reference

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Phosphatidate-dependent protein phosphorylation

5 July 2018

1 reference

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The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions.

5 July 2018

1 reference

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Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Involvement of phospholipids in the mechanism of insulin action in HEPG2 cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Phospholipase D confers rapamycin resistance in human breast cancer cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928642

Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth

28 October 2018

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12 December 2020

Stimulation of protein synthesis by phosphatidic acid in rat cardiomyocytes

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12 December 2020

Responses of heart function and intracellular free Ca2 to phosphatidic acid in chronic diabetes

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12 December 2020

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR

1 reference

12 December 2020

Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

1 reference

12 December 2020

10.1152/AJPCELL.00039.2010

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference