The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins (Q34079605)

30 July 2017

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title

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins (English)

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30 July 2017

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Selkoe DJ

1

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30 July 2017

publication date

1 November 2000

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30 July 2017

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30 July 2017

volume

18

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30 July 2017

issue

4

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30 July 2017

page(s)

903-922

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

30 July 2017

cites work

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

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7 January 2021

Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing

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7 January 2021

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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7 January 2021

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Inflammatory mechanisms in Alzheimer's disease.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

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7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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7 January 2021

Tau mutations cause frontotemporal dementias

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Plaque-only Alzheimer disease is usually the lewy body variant, and vice versa.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

One of the antigenic determinants of paired helical filaments is related to tau protein

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Evidence for a physical interaction between presenilin and Notch

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Inflammation and Alzheimer's disease pathogenesis

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

1 reference

7 January 2021

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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https://api.crossref.org/works/10.1016/S0733-8619(05)70232-2

7 January 2021

10.1016/S0733-8619(05)70232-2

Identifiers

DOI

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30 July 2017

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