CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. (Q34064274)

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28 October 2019

title

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration (English)

1 reference

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28 October 2019

author name string

Brady HJ

1

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28 October 2019

Pennington DJ

2

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28 October 2019

Miles CG

3

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28 October 2019

Dzierzak EA

4

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28 October 2019

language of work or name

English

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publication date

1 December 1993

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28 October 2019

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28 October 2019

volume

12

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28 October 2019

issue

13

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28 October 2019

page(s)

4923-4932

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The SCID-hu mouse as a model for HIV-1 infection

28 October 2019

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28 July 2018

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The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Current issues in developing a strategy for dealing with the acquired immunodeficiency syndrome

28 July 2018

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Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses

28 July 2018

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

28 July 2018

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The structure of the CD4 and CD8 genes

28 July 2018

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Polymorphism of the 3' open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III.

28 July 2018

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Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4 cell depletion

28 July 2018

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Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4 cells: mechanism for persistence in AIDS.

28 July 2018

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Expression and function of the CD3-antigen receptor on murine CD4 8 thymocytes

28 July 2018

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The structure of the human CD2 gene and its expression in transgenic mice

28 July 2018

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Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor

28 July 2018

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Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

28 July 2018

1 reference

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The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

28 July 2018

1 reference

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Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

28 July 2018

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DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression

28 July 2018

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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta and TCR gamma delta to human immunodeficiency virus infection: a mechanism for CD4 (T4) lymphocyte depleti

28 July 2018

1 reference

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CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

28 July 2018

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Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

28 July 2018

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An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor

28 July 2018

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Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

28 July 2018

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

28 July 2018

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

28 July 2018

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Mice lacking MHC class II molecules

28 July 2018

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Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme

28 July 2018

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Normal development and function of CD8 cells but markedly decreased helper cell activity in mice lacking CD4

28 July 2018

1 reference

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Molecular biology of the human immunodeficiency virus type 1

28 July 2018

1 reference

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In vitro studies of HIV-1 infection in thymic lymphocytes: a putative role of the thymus in AIDS pathogenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

In vitro studies of HIV-1 expression in thymocytes from infants and children

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

High level of surface CD4 prevents stable human immunodeficiency virus infection of T-cell transfectants

28 July 2018

1 reference

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Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413753

Activation pathways and human immunodeficiency virus type 1 replication are not altered in CD4 T cells expressing the nef protein.

28 July 2018

1 reference

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28 July 2018

How does HIV cause AIDS?

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HIV induces thymus depletion in vivo

28 October 2018

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A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues

28 October 2018

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12 December 2020

Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR

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12 December 2020

Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

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12 December 2020

Expression and function of CD2 during murine thymocyte ontogeny

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12 December 2020

Mutational analysis of the HIV nef protein

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12 December 2020

Frequent and early in utero HIV-1 infection

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12 December 2020

The HIV-1 nef protein does not have guanine nucleotide binding, GTPase, or autophosphorylating activities

1 reference

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Selective inactivation of influenza C esterase: a probe for detecting 9-O-acetylated sialic acids

1 reference

12 December 2020

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

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12 December 2020

Murine CD2 gene expression during fetal thymus ontogeny

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12 December 2020

10.1002/J.1460-2075.1993.TB06186.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8262036 AND SRC:MED&resulttype=core&format=json

28 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8262036 AND SRC:MED&resulttype=core&format=json

28 October 2019

PubMed publication ID

8262036

1 reference