Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction (Q34063712)

25147610

30 July 2017

title

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction (English)

1 reference

30 July 2017

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

29

Daqing Sun

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

22

Xuelei Yan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

23

Qiuping Ye

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Ming Yu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Yingcai Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jiang Zhu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Michael D Bartberger

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jude Canon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Ada Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

David Chow

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

John Eksterowicz

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Brian Fox

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jiasheng Fu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Michael Gribble

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Xin Huang

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Zhihong Li

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jiwen Jim Liu

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Mei-Chu Lo

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Dustin McMinn

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jonathan D Oliner

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Tao Osgood

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Yosup Rew

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Paul Shaffer

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Dongyin Yu

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Xiaoning Zhao

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Jing Zhou

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Steven H Olson

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

Julio C Medina

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

1 reference

30 June 2014

1 reference

25147610

ACS Medicinal Chemistry Letters

30 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

894-899

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

The genetics of the p53 pathway, apoptosis and cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

5 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

p53 and human cancer: the first ten thousand mutations.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Amplification of a gene encoding a p53-associated protein in human sarcomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4137378

Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic

5 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25147610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML500142B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25147610 AND SRC:MED&resulttype=core&format=json

5 June 2020

25147610

1 reference